Evidence map›Paper›PMID 19849853›Full record

ReviewReproductive biology and endocrinology : RB&E2009

Pathophysiology of cell phone radiation: oxidative stress and carcinogenesis with focus on male reproductive system.

Nisarg R Desai, Kavindra K Kesari, Ashok Agarwal

Registry-linked trialOpen access · goldAbstract readEvaluation StudyReview
In one paragraph

Review in Reproductive biology and endocrinology : RB&E, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04541459 (Validation of New Devices Against Ambient Electromagnetic Radiation), which is not on this map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
12.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04541459 early_phase1unknown statusnot on this mapstarted 2020, after this paper: background citation

Validation of New Devices Against Ambient Electromagnetic Radiation: A Randomized Double Blind Controlled Study

TypeinterventionalSponsorWaveguard GmbHRan2020 to 2021Enrolled40ConditionsMale InfertilityArmsnew device against ambient electromagnetic radiation, sham device against ambient electromagnetic radiation
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 195 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Oxidative Stress and Idiopathic Male Infertility.Advances in experimental medicine and biology · 2022
    Review
  13. Methodology of Studying Effects of Mobile Phone Radiation on Organisms: Technical Aspects.International journal of environmental research and public health · 2021
    Article
  14. Article
  15. Oxidative stress and male infertility.Reproductive medicine and biology · 2021
    Review
  16. Sperm DNA Fragmentation: A New Guideline for Clinicians.The world journal of men's health · 2020
    Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Nisarg R DesaiCenter for Reproductive Medicine, Glickman Urological and Kidney Institute and Obstetrics and Gynecology and Women's Health Institute, Cleveland Clinic, Cleveland, Ohio, USA. nisargdesai@hotmail.com
Kavindra K Kesari
Ashok Agarwal
Cleveland Clinic · USJawaharlal Nehru University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hazardous health effects stemming from exposure to radiofrequency electromagnetic waves (RF-EMW) emitted from cell phones have been reported in the literature. However, the cellular target of RF-EMW is still controversial. This review identifies the plasma membrane as a target of RF-EMW. In addition, the effects of RF-EMW on plasma membrane structures (i.e. NADH oxidase, phosphatidylserine, ornithine decarboxylase) and voltage-gated calcium channels are discussed. We explore the disturbance in reactive oxygen species (ROS) metabolism caused by RF-EMW and delineate NADH oxidase mediated ROS formation as playing a central role in oxidative stress (OS) due to cell phone radiation (with a focus on the male reproductive system). This review also addresses: 1) the controversial effects of RF-EMW on mammalian cells and sperm DNA as well as its effect on apoptosis, 2) epidemiological, in vivo animal and in vitro studies on the effect of RF-EMW on male reproductive system, and 3) finally, exposure assessment and dosimetry by computational biomodeling.

Indexed as

Cell PhoneAnimalsCarcinomaGenitalia, MaleGenital Neoplasms, MaleHumansMaleModels, BiologicalNeoplasms, Radiation-InducedOxidative StressRadiation

Identifiers

PMID19849853
PMCPMC2776019
OpenAlexW2140249537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.