ArticlePMC biophysics2009
Simple modeling of FtsZ polymers on flat and curved surfaces: correlation with experimental in vitro observations.
Article in PMC biophysics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 28 citations in OpenAlex.
- How Does the Spatial Confinement of FtsZ to a Membrane Surface Affect Its Polymerization Properties and Function?Frontiers in microbiology · 2022Review
- A stochastic model for dynamics of FtsZ filaments and the formation of Z -ring.The European physical journal. E, Soft matter · 2020Article
- Insights into the Structure, Function, and Dynamics of the Bacterial Cytokinetic FtsZ-Ring.Annual review of biophysics · 2020Review
- Surface Orientation and Binding Strength Modulate Shape of FtsZ on Lipid Surfaces.International journal of molecular sciences · 2019Article
- Beyond force generation: Why is a dynamic ring of FtsZ polymers essential for bacterial cytokinesis?BioEssays : news and reviews in molecular, cellular and developmental biology · 2017Review
- Defining the rate-limiting processes of bacterial cytokinesis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Cell shape can mediate the spatial organization of the bacterial cytoskeleton.Biophysical journal · 2013Article
- Depolymerization dynamics of individual filaments of bacterial cytoskeletal protein FtsZ.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- FtsZ in bacterial cytokinesis: cytoskeleton and force generator all in one.Microbiology and molecular biology reviews : MMBR · 2010Review
- Discovery of anti-TB agents that target the cell-division protein FtsZ.Future medicinal chemistry · 2010Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
FtsZ is a GTPase that assembles at midcell into a dynamic ring that constricts the membrane to induce cell division in the majority of bacteria, in many archea and several organelles. In vitro, FtsZ polymerizes in a GTP-dependent manner forming a variety of filamentous flexible structures. Based on data derived from the measurement of the in vitro polymerization of Escherichia coli FtsZ cell division protein we have formulated a model in which the fine balance between curvature, flexibility and lateral interactions accounts for structural and dynamic properties of the FtsZ polymers observed with AFM. The experimental results have been used by the model to calibrate the interaction energies and the values obtained indicate that the filaments are very plastic. The extension of the model to explore filament behavior on a cylindrical surface has shown that the FtsZ condensates promoted by lateral interactions can easily form ring structures through minor modulations of either filament curvature or longitudinal bond energies. The condensation of short, monomer exchanging filaments into rings is shown to produce enough force to induce membrane deformations.PACS codes: 87.15.ak, 87.16.ka, 87.17.Ee.
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