ArticleBMC cancer2009
Clinical meaning of age-related expression of fecal cytokeratin 19 in colorectal malignancy.
Article in BMC cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Pooled it
- Plasma Circulating mRNA Profile for the Non-Invasive Diagnosis of Colorectal Cancer Using NanoString Technologies.International journal of molecular sciences · 2024Article
- Colonocyte keratin 7 is expressed de novo in inflammatory bowel diseases and associated with pathological changes and drug-resistance.Scientific reports · 2022Article
- Predicting prognosis for patients with ESCC before surgery by SVMs ranking with nomogram analyses.American journal of translational research · 2022Article
- The correlation between common postoperative complications and quality of life, serum tumor markers, and prognosis in patients with esophageal cancer.Translational cancer research · 2022Article
- Expression pattern of placenta specific 8 and keratin 20 in different types of gastrointestinal cancer.Molecular medicine reports · 2020Article
- Discovery of genes from feces correlated with colorectal cancer progression.Oncology letters · 2016Article
- Knocking down of heat-shock protein 27 directs differentiation of functional glutamatergic neurons from placenta-derived multipotent cells.Scientific reports · 2016Article
- Cell budding from normal appearing epithelia: a predictor of colorectal cancer metastasis?International journal of biological sciences · 2013Article
- Analysis of tumor-induced lymphangiogenesis and lymphatic vessel invasion of pancreatic carcinoma in the peripheral nerve plexus.Cancer science · 2012Article
- Preoperative Cyfra21-1 and SCC-Ag serum titers predict survival in patients with stage II esophageal squamous cell carcinoma.Journal of translational medicine · 2012Article
- High mitochondrial DNA copy number and bioenergetic function are associated with tumor invasion of esophageal squamous cell carcinoma cell lines.International journal of molecular sciences · 2012Article
- Lowly expressed ribosomal protein s19 in the feces of patients with colorectal cancer.ISRN gastroenterology · 2012Article
- A predicted protein, KIAA0247, is a cell cycle modulator in colorectal cancer cells under 5-FU treatment.Journal of translational medicine · 2011Article
- Cytokeratin 19 expression patterns of dentigerous cysts and odontogenic keratocysts.Annals of medical and health sciences researchArticle
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundColorectal cancer (CRC) is one of the leading causes of malignant death worldwide. Because young age of onset is often considered a poor prognostic factor for CRC, it is important to identify the poor outcomes of CRC in a younger population and to consider an aggressive approach by implementing early treatment. Our aim was to specifically quantify the fecal cytokeratin 19 (CK19) transcript from CRC patients and investigate its correlation with clinical stage, tumor malignancy, and age.
methodsThe quantitation of fecal CK19 transcript was determined by a quantitative real-time reverse transcription polymerase chain in 129 CRC patients (45 younger than 60 years at diagnosis) and 85 healthy controls. The levels of CK19 protein were examined both in colonic cell lines and tissues.
resultsThe analysis of 45 younger CRC patients (age <or= 60 years) revealed that patients at the M1 stage had significantly higher expression levels of fecal CK19 mRNA when compared with healthy controls (p < 0.001) and patients at the M0 stage (p = 0.004). Additionally, the degree of consistency between the mean level of fecal CK19 mRNA and the distant metastatic rate in each age interval was up to 89% (p = 0.042).
conclusionThese results indicate that high levels of fecal CK19 mRNA represent a potential marker for colorectal malignancy and for aggressive treatment of younger CRC patients.
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