ArticleThe Journal of infectious diseases2009
Human Papillomavirus (HPV) type 16 and type 18 DNA Loads at Baseline and Persistence of Type-Specific Infection during a 2-year follow-up.
Article in The Journal of infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Higher HPV16 and HPV18 Penile Viral Loads Are Associated With Decreased Human Papillomavirus Clearance in Uncircumcised Kenyan Men.Sexually transmitted diseases · 2016Trial
- Association of Human Papillomavirus 31 DNA Load with Risk of Cervical Intraepithelial Neoplasia Grades 2 and 3.Journal of clinical microbiology · 2015Trial
- Acquisition and persistence of human papillomavirus 16 (HPV-16) and HPV-18 among men with high-HPV viral load infections in a circumcision trial in Kisumu, Kenya.The Journal of infectious diseases · 2015Trial
- Male circumcision decreases high-risk human papillomavirus viral load in female partners: a randomized trial in Rakai, Uganda.International journal of cancer · 2013Trial
- Initial different human papillomavirus infection statuses and subsequent infection risk: a decade-long longitudinal study.Journal of health, population, and nutrition · 2025Article
- Strategic Significance of Low Viral Load of Human Papillomavirus in Uterine Cervical Cytology Specimens.Diagnostics (Basel, Switzerland) · 2022Article
- A comprehensive HPV-STI NGS assay for detection of 29 HPV types and 14 non-HPV sexually transmitted infections.Infectious agents and cancer · 2022Article
- The DNA load of six high-risk human papillomavirus types and its association with cervical lesions.BMC cancer · 2015Article
- From Human Papillomavirus (HPV) Detection to Cervical Cancer Prevention in Clinical Practice.Cancers · 2014Article
- Tobacco exposure results in increased E6 and E7 oncogene expression, DNA damage and mutation rates in cells maintaining episomal human papillomavirus 16 genomes.Carcinogenesis · 2014Article
- High-risk oral human papillomavirus load in the US population, National Health and Nutrition Examination Survey 2009-2010.The Journal of infectious diseases · 2014Article
- High-risk human papillomavirus viral load and persistence among heterosexual HIV-negative and HIV-positive men.Sexually transmitted infections · 2014Article
- Viral load and short-term natural history of type-specific oncogenic human papillomavirus infections in a high-risk cohort of midadult women.International journal of cancer · 2014Article
- Changes in type-specific human papillomavirus load predict progression to cervical cancer.Journal of cellular and molecular medicine · 2012Article
- Serum antibody response following genital {alpha}9 human papillomavirus infection in young men.The Journal of infectious diseases · 2011Article
- Viral load in the natural history of human papillomavirus type 16 infection: a nested case-control study.The Journal of infectious diseases · 2011Article
- HPV genotype detection using hybrid capture sample preparation combined with whole genome amplification and multiplex detection with Luminex XMAP.The Journal of molecular diagnostics : JMD · 2010Article
- Tobacco smoking and regression of low-grade cervical abnormalities.Cancer science · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundStudies of viral load-associated persistence of human papillomavirus (HPV) infection are rare, with inconsistent results reported.
methodsThe study subjects were 741 and 289 women who were positive for HPV type 16 (HPV-16) and HPV type 18 (HPV-18), respectively, at the time of enrollment into in the ASCUS-LSIL (Atypical Squamous Cells of Undetermined Significance-Low-Grade Squamous Intraepithelial Lesion) Triage Study and who returned 1 or more times for HPV testing during a biannual 2-year follow-up. The numbers of HPV-16 and HPV-18 copies per nanogram of cellular DNA at baseline were measured by use of real-time polymerase chain reaction.
resultsWomen with, compared with women without, persistent infection at month 6 of follow-up had a higher viral load at enrollment (P< .001, for HPV-16; P=.01, for HPV-18). The association of each 1-log(10) increase in viral load with persistence of HPV-16 or HPV-18 during the first 6 months of the study was statistically significant among women with multiple HPV types at enrollment (for HPV-16: odds ratio [OR], 1.53 [95% confidence interval {CI}, 1.29-1.82]; for HPV-18: OR, 1.35 [95% CI, 1.09-1.68]) but not among women with monotype infections (in tests assessing the interaction between viral load and coinfection, P=.002 for HPV-16 and P=.34 for HPV-18). Among women who continued to have positive results at month 6, 12, or 18, persistence of infection for another 6 months was unassociated with the viral load at baseline.
conclusionPrevalent infection with a higher viral load of HPV-16 or HPV-18 was associated with short- but not long-term persistence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.