ArticleDrugs & aging2009
Effects of potent anticholinergics, sedatives and antipsychotics on postoperative mortality in elderly patients with hip fracture: a retrospective, population-based study.
Article in Drugs & aging, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Association between anticholinergic drug burden and mortality in older people: a systematic review.European journal of clinical pharmacology · 2020Pooled it
- Drugs with anticholinergic effects and cognitive impairment, falls and all-cause mortality in older adults: A systematic review and meta-analysis.British journal of clinical pharmacology · 2015Pooled it
- Anticholinergic burden quantified by anticholinergic risk scales and adverse outcomes in older people: a systematic review.BMC geriatrics · 2015Pooled it
- Impact of anticholinergic discontinuation on cognitive outcomes in older people: a systematic review.Drugs & aging · 2014Pooled it
- Effect of anticholinergic burden on cardiac functions in older patients.Zeitschrift fur Gerontologie und Geriatrie · 2026Article
- The effects of concurrent oral paliperidone or risperidone use with paliperidone long-acting injection.The mental health clinician · 2021Article
- Anticholinergics May Carry Significant Cognitive and Gait Burden in Parkinson's Disease.Movement disorders clinical practice · 2020Article
- Evaluation of the impact of sedative medication in patients admitted with a fractured neck of femur.Clinical medicine (London, England) · 2020Article
- All-cause mortality with current and past use of antidepressants or benzodiazepines after major osteoporotic and hip fracture.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Article
- Anticholinergic burden and health outcomes among older adults discharged from hospital: results from the CRIME study.European journal of clinical pharmacology · 2017Article
- Risk of Mortality Associated with Anticholinergic Use in Elderly Nursing Home Residents with Depression.Drugs & aging · 2017Article
- Examination and Estimation of Anticholinergic Burden: Current Trends and Implications for Future Research.Drugs & aging · 2016Article
- Central Anticholinergic Adverse Effects and Their Measurement.Drugs & aging · 2015Article
- Total anticholinergic burden and risk of mortality and cardiovascular disease over 10 years in 21,636 middle-aged and older men and women of EPIC-Norfolk prospective population study.Age and ageing · 2015Observational
- Effect of Anticholinergic Medications on Falls, Fracture Risk, and Bone Mineral Density Over a 10-Year Period.The Annals of pharmacotherapy · 2014Article
- Article
- Association of anticholinergic drugs with hospitalization and mortality among older cardiovascular patients: A prospective study.Drugs & aging · 2011Article
- Anticholinergic drugs and their effects on delirium and mortality in the elderly.Dementia and geriatric cognitive disorders extra · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConcomitant use of several medications for somatic and mental disorders is common in elderly people and increases the risk of falls, with hip fracture being the most serious consequence.
objectiveThe objective of this study was to describe relationships between use of sedatives, antipsychotics or potent anticholinergics and postoperative mortality in patients with hip fractures.
methodsA retrospective analysis was conducted on population-based data collected during a 2-year period from 1999 to 2000 on 461 hip fracture surgery patients aged > or = 65 years in Finland. Information on co-morbidities and intake of sedatives, antipsychotics and potent anticholinergics was obtained from the original patient records. Information on deaths was obtained from the official death statistics in Finland.
resultsIn men, use of potent anticholinergics was associated with excess age-adjusted mortality at 30 days, 3 months, 6 months and 3 years, but not in women at any timepoint.
conclusionUse of potent anticholinergic drugs emerged as an independent predictor of excess mortality in men at 3 months and 3 years. Presence of cardiovascular disease and chronic lung disease were independent risk factors for excess mortality at 6 months and 3 years in men. In addition, chronic lung disease independently predicted excess mortality at 30 days. Use of potent anticholinergics should be evaluated critically after hip fracture surgery, especially in men with cardiovascular or chronic lung diseases.
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