ArticleTransgenic research2010
Consumption of pasteurized human lysozyme transgenic goats' milk alters serum metabolite profile in young pigs.
Article in Transgenic research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 48 citations in OpenAlex.
- Leverage of lysozyme dietary supplementation on gut health, hematological, antioxidant, and immune parameters in different plumage-colors Japanese quails.Poultry science · 2025Article
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- Large-scale production of recombinant human lactoferrin from high-expression, marker-free transgenic cloned cows.Scientific reports · 2017Article
- Rice Bran and Probiotics Alter the Porcine Large Intestine and Serum Metabolomes for Protection against Human Rotavirus Diarrhea.Frontiers in microbiology · 2017Article
- Large-scale production of functional human lysozyme from marker-free transgenic cloned cows.Scientific reports · 2016Article
- Molecular Cloning and Characterization of a New C-type Lysozyme Gene from Yak Mammary Tissue.Asian-Australasian journal of animal sciences · 2015Article
- Production of human lactoferrin and lysozyme in the milk of transgenic dairy animals: past, present, and future.Transgenic research · 2015Review
- Lysozyme as an alternative to growth promoting antibiotics in swine production.Journal of animal science and biotechnology · 2015Article
- Assessing unintended effects of a mammary-specific transgene at the whole animal level in host and non-target animals.Transgenic research · 2014Article
- Consuming transgenic goats' milk containing the antimicrobial protein lysozyme helps resolve diarrhea in young pigs.PloS one · 2013Article
- Consumption of lysozyme-rich milk can alter microbial fecal populations.Applied and environmental microbiology · 2012Article
- Lysozyme transgenic goats' milk positively impacts intestinal cytokine expression and morphology.Transgenic research · 2011Article
- Characterization of bioactive recombinant human lysozyme expressed in milk of cloned transgenic cattle.PloS one · 2011Article
- Evaluating the fitness of human lysozyme transgenic dairy goats: growth and reproductive traits.Transgenic research · 2010Article
- Precision genetics for complex objectives in animal agriculture.Journal of animal science · 2010Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nutrition, bacterial composition of the gastrointestinal tract, and general health status can all influence the metabolic profile of an organism. We previously demonstrated that feeding pasteurized transgenic goats' milk expressing human lysozyme (hLZ) can positively impact intestinal morphology and modulate intestinal microbiota composition in young pigs. The objective of this study was to further examine the effect of consuming hLZ-containing milk on young pigs by profiling serum metabolites. Pigs were placed into two groups and fed a diet of solid food and either control (non-transgenic) goats' milk or milk from hLZ-transgenic goats for 6 weeks. Serum samples were collected at the end of the feeding period and global metabolite profiling was performed. For a total of 225 metabolites (160 known, 65 unknown) semi-quantitative data was obtained. Levels of 18 known and 4 unknown metabolites differed significantly between the two groups with the direction of change in 13 of the 18 known metabolites being almost entirely congruent with improved health status, particularly in terms of the gastrointestinal tract health and immune response, with the effects of the other five being neutral or unknown. These results further support our hypothesis that consumption of hLZ-containing milk is beneficial to health.
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