ArticlePituitary2010
Hypopituitarism due to sports related head trauma and the effects of growth hormone replacement in retired amateur boxers.
Article in Pituitary, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Effect of Growth Hormone on Neuropsychological Outcomes and Quality of Life of Patients with Traumatic Brain Injury: A Systematic Review.Journal of neurotrauma · 2021Pooled it
- Effect of growth hormone replacement therapy on cognition after traumatic brain injury.Journal of neurotrauma · 2010Trial
- Neuroendocrine Disruptions Following Head Injury.Current neurology and neuroscience reports · 2023Review
- Traumatic Brain Injury as Frequent Cause of Hypopituitarism and Growth Hormone Deficiency: Epidemiology, Diagnosis, and Treatment.Frontiers in endocrinology · 2021Review
- Peripheral blood neuroendocrine hormones are associated with clinical indices of sport-related concussion.Scientific reports · 2019Article
- Growth Hormone Deficiency Following Traumatic Brain Injury.International journal of molecular sciences · 2019Review
- Review
- Review
- The frequency and the diagnosis of pituitary dysfunction after traumatic brain injury.Pituitary · 2019Review
- Growth hormone deficiency and hypopituitarism in adults after complicated mild traumatic brain injury.Endocrine · 2017Article
- Advances in understanding hypopituitarism.F1000Research · 2017Review
- Evaluation of long-term pituitary functions in patients with severe ventricular arrhythmia: a pilot study.Journal of endocrinological investigation · 2014Article
- Prevalence of pituitary hormone dysfunction, metabolic syndrome, and impaired quality of life in retired professional football players: a prospective study.Journal of neurotrauma · 2014Article
- Influence of physical exercise on traumatic brain injury deficits: scaffolding effect.Neurotoxicity research · 2012Review
- High prevalence of chronic pituitary and target-organ hormone abnormalities after blast-related mild traumatic brain injury.Frontiers in neurology · 2012Article
- Hypopituitarism following traumatic brain injury: determining factors for diagnosis.Frontiers in endocrinology · 2011Article
- Pituitary and/or hypothalamic dysfunction following moderate to severe traumatic brain injury: Current perspectives.Indian journal of endocrinology and metabolismReview
- Manifesto for the current understanding and management of traumatic brain injury-induced hypopituitarism.Journal of endocrinological investigationArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traumatic brain injury (TBI) has been recently recognized as a leading cause of pituitary dysfunction. Current data clearly demonstrated that sports related head trauma due to boxing, kickboxing, and soccer might results in pituitary hormone deficiencies, isolated growth hormone (GH) deficiency in particular. In the present report physiologic dose GH replacement therapy (GHRT) was performed in two GH deficient retired amateur boxers for the first time. The boxers received recombinant GH for 6 months. After 6 months of GHRT there were substantial improvements, but not complete normalization, in the body composition parameters, lipid profiles and quality of life scores in both boxers. These preliminary results suggest that GHRT may have beneficial effects in retired boxers with severe isolated GH deficiency due to sports related head trauma. But more data with higher number of boxers and longer GHRT duration are warranted.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.