ArticlePediatric radiology2010
1H-MRS for the diagnosis of acute disseminated encephalomyelitis: insight into the acute-disease stage.
Article in Pediatric radiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- A systematic approach to MR spectroscopy of the brain: Indications, protocol, metabolites, and spectral analysis in neurologic diseases.The neuroradiology journal · 2026Review
- Brain Metabolite Differences in Fetuses With Cytomegalovirus Infection: A Magnetic Resonance Spectroscopy Study.Journal of magnetic resonance imaging : JMRI · 2025Article
- Pediatric Neuroimaging of Multiple Sclerosis and Neuroinflammatory Diseases.Tomography (Ann Arbor, Mich.) · 2024Review
- Metabolic Profiling of Suprachiasmatic Nucleus Reveals Multifaceted Effects in an Alzheimer's Disease Mouse Model.Journal of Alzheimer's disease : JAD · 2021Article
- MR spectroscopy in children: protocols and pitfalls in non-tumorous brain pathology.Pediatric radiology · 2016Review
- The magnetic resonance imaging appearance of monophasic acute disseminated encephalomyelitis: an update post application of the 2007 consensus criteria.Neuroimaging clinics of North America · 2013Review
- Metabolic profile of PML lesions in patients with and without IRIS: an observational study.Neurology · 2012Article
- A differential diagnosis of central nervous system demyelination: beyond multiple sclerosis.Journal of neurology · 2012Review
- Post-traumatic acute disseminated encephalomyelitis.Radiology case reports · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute disseminated encephalomyelitis (ADEM) is a demyelinating disorder of the central nervous system (CNS). Differentiating ADEM from other inflammatory disorders, such as multiple sclerosis, is not always conclusive using conventional MRI.
objectiveTo evaluate longitudinal magnetic resonance spectroscopy (MRS) changes that distinguish ADEM from other inflammatory disorders. MATERIALS AND
methodsMRI/MRS scans were performed in seven patients with ADEM during the acute and chronic phases of the disease.
resultsPartial recovery was detected between the acute and chronic phases in choline/creatine ratio. Major elevation of lipids and reduction in myo-inositol/creatine ratio was detected in all patients during the acute phase, followed by a reduction in lipids peak and elevation above normal in myo-inositol/creatine ratio during the chronic phase.
conclusionConsistent and unique MRS changes in metabolite ratios between the acute and chronic presentations of the disease were found. To the best of our knowledge, these patterns have not been described in other inflammatory disorders and might assist in the early diagnosis of ADEM.
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