Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2010
Serotonergic and noradrenergic modulation of emotion processing by single dose antidepressants.
Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 63 citations in OpenAlex.
- Behavioral intervention with task repetition compared to pharmacological intervention with SSRI for enhancement of cognitive control in emotional and non-emotional settings.Psychopharmacology · 2025Trial
- Amygdala activity after subchronic escitalopram administration in healthy volunteers: A pharmaco-functional magnetic resonance imaging study.Journal of psychopharmacology (Oxford, England) · 2024Trial
- Baseline Perfusion Alterations Due to Acute Application of Quetiapine and Pramipexole in Healthy Adults.The international journal of neuropsychopharmacology · 2016Trial
- Effects of Escitalopram Administration on Face Processing in Intermittent Explosive Disorder: An fMRI Study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- Impact of acute administration of escitalopram on the processing of emotional and neutral images: a randomized crossover fMRI study of healthy women.Journal of psychiatry & neuroscience : JPN · 2014Trial
- Depression symptom dimensions as predictors of antidepressant treatment outcome: replicable evidence for interest-activity symptoms.Psychological medicine · 2012Trial
- Paroxetine reduces crying in young women watching emotional movies.Psychopharmacology · 2012Trial
- Dopamine and serotonin neurotransmissions exert complementary control over primate approach and avoidance.Translational psychiatry · 2025Article
- Behavioral, cortical and autonomic effects of single-dose escitalopram on the induction and regulation of fear and disgust: Comparison with single-session psychological emotion regulation with reappraisal.Frontiers in psychiatry · 2022Article
- Transcutaneous auricular vagus nerve immediate stimulation treatment for treatment-resistant depression: A functional magnetic resonance imaging study.Frontiers in neurology · 2022Article
- Selective serotonin reuptake inhibitor treatment retunes emotional valence in primate ventral striatum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Impact of FAAH genetic variation on fronto-amygdala function during emotional processing.European archives of psychiatry and clinical neuroscience · 2019Article
- Cortisol and Major Depressive Disorder-Translating Findings From Humans to Animal Models and Back.Frontiers in psychiatry · 2019Review
- Central serotonin modulates neural responses to virtual violent actions in emotion regulation networks.Brain structure & function · 2018Article
- Neural Correlates of Social Inclusion in Borderline Personality Disorder.Frontiers in psychiatry · 2018Article
- Altered Functional Magnetic Resonance Imaging Markers of Affective Processing During Treatment of Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2016Article
- Healthy individuals treated with clomipramine: an fMRI study of brain activity during autobiographical recall of emotions.Translational psychiatry · 2014Article
- Imaging the pathophysiology of major depressive disorder - from localist models to circuit-based analysis.Biology of mood & anxiety disorders · 2014Article
- Aberrant intrinsic connectivity of hippocampus and amygdala overlap in the fronto-insular and dorsomedial-prefrontal cortex in major depressive disorder.Frontiers in human neuroscience · 2013Article
- Effects of swim stress and fluoxetine on 5-HT1A receptor gene expression and monoamine metabolism in the rat brain regions.Cellular and molecular neurobiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serotonergic and noradrenergic pathways are the main targets of antidepressants. Their differential effects on emotion processing-related brain activation are, however, to be further characterized. We aimed at elucidating the neural sites of action of an acute differential serotonergic and noradrenergic influence on an emotion-processing task, which was earlier shown to be associated with depressiveness. In a single-blind pseudo-randomized crossover study, 21 healthy subjects (16 subjects finally included in the analysis) participated to ingest a single dose at three time points of either 40 mg citalopram, a selective serotonin-reuptake inhibitor, 8 mg reboxetine, a selective noradrenaline-reuptake inhibitor, or placebo 2-3 h before functional magnetic resonance imaging (fMRI). During fMRI, subjects performed a task comprising the anticipation and perception of pictures of either 'known' (positive, negative, neutral) or 'unknown' valence (randomly 50% positive or negative). In direct comparison with citalopram and with placebo, reboxetine increased brain activity in the medial thalamus. Citalopram modulated certain prefrontal and insular areas more prominently. Other frontal and parieto-occipital areas were modulated by both drugs. In conclusion, the functional network involved in emotional information processing could be modulated by the acute application of selective noradrenergic and serotonergic drugs revealing a noradrenergic effect in thalamic and frontal areas, and a prefrontal and insular focus of serotonergic modulation. These findings could have implications for future selection criteria concerning personalized antidepressant medication in depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.