ArticleDiabetes2010
Chronic maternal dietary chromium restriction modulates visceral adiposity: probable underlying mechanisms.
Article in Diabetes, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 63 citations in OpenAlex.
- Gene Dynamics in Maternal Nutrition: The Role of Chromium in Mitigating Offspring Obesity.Biological trace element research · 2026Article
- Chromium restriction in the intrauterine environment and development of metabolic diseases in mice offspring.Journal of Taibah University Medical Sciences · 2025Article
- Association between blood chromium and hepatic steatosis assessed by liver ultrasound transient elastography: National Health and Nutrition Examination Survey 2017-2020.Frontiers in nutrition · 2024Article
- Joint Effect of Multiple Metals on Hyperuricemia and Their Interaction with Obesity: A Community-Based Cross-Sectional Study in China.Nutrients · 2023Article
- Nano Chromium Picolinate Improves Gene Expression Associated with Insulin Signaling in Porcine Skeletal Muscle and Adipose Tissue.Animals : an open access journal from MDPI · 2020Article
- Olanzapine Induced Dysmetabolic Changes Involving Tissue Chromium Mobilization in Female Rats.International journal of molecular sciences · 2019Article
- Interventions to Address Environmental Metabolism-Disrupting Chemicals: Changing the Narrative to Empower Action to Restore Metabolic Health.Frontiers in endocrinology · 2019Review
- Effects of chromium picolinate on fat deposition, activity and genetic expression of lipid metabolism-related enzymes in 21 day old Ross broilers.Asian-Australasian journal of animal sciences · 2018Article
- Maternal chromium restriction modulates miRNA profiles related to lipid metabolism disorder in mice offspring.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- The effect of maternal chromium status on lipid metabolism in female elderly mice offspring and involved molecular mechanism.Bioscience reports · 2017Article
- Article
- Effects of Maternal Chromium Restriction on the Long-Term Programming in MAPK Signaling Pathway of Lipid Metabolism in Mice.Nutrients · 2016Article
- Severe but Not Moderate Vitamin B12 Deficiency Impairs Lipid Profile, Induces Adiposity, and Leads to Adverse Gestational Outcome in Female C57BL/6 Mice.Frontiers in nutrition · 2016Article
- Gene-environment interactions controlling energy and glucose homeostasis and the developmental origins of obesity.Physiological reviews · 2015Review
- Maternal diet, bioactive molecules, and exercising as reprogramming tools of metabolic programming.European journal of nutrition · 2014Review
- You are what you eat, and so are your children: the impact of micronutrients on the epigenetic programming of offspring.Cellular and molecular life sciences : CMLS · 2014Review
- Article
- Metabolic syndrome: role of maternal undernutrition and fetal programming.Reviews in endocrine & metabolic disorders · 2013Review
- Leaching of heavy metals from water bottle components into the drinking water of rodents.Journal of the American Association for Laboratory Animal Science : JAALAS · 2013Article
- Maternal micronutrient restriction programs the body adiposity, adipocyte function and lipid metabolism in offspring: a review.Reviews in endocrine & metabolic disorders · 2012Review
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe demonstrated previously that chronic maternal micronutrient restriction altered the body composition in rat offspring and may predispose offspring to adult-onset diseases. Chromium (Cr) regulates glucose and fat metabolism. The objective of this study is to determine the long-term effects of maternal Cr restriction on adipose tissue development and function in a rat model. RESEARCH DESIGN AND
methodsFemale weanling WNIN rats received, ad libitum, a control diet or the same with 65% restriction of Cr (CrR) for 3 months and mated with control males. Some pregnant CrR mothers were rehabilitated from conception or parturition and their pups weaned to control diet. Whereas some CrR offspring were weaned to control diet, others continued on CrR diet. Various parameters were monitored in the offspring at three monthly intervals up to 15-18 months of age.
resultsMaternal Cr restriction significantly increased body weight and fat percentage, especially the central adiposity in both male and female offspring. Further, the expression of leptin and 11 beta-hydroxysteroid dehydrogenase 1 genes were significantly increased in CrR offspring of both the sexes. Adipocytokine levels were altered in plasma and adipose tissue; circulating triglyceride and FFA levels were increased, albeit in female offspring only. Rehabilitation regimes did not correct body adiposity but restored the circulating levels of lipids and adipocytokines.
conclusionsChronic maternal Cr restriction increased body adiposity probably due to increased stress and altered lipid metabolism in WNIN rat offspring, which may predispose them to obesity and associated diseases in later life.
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