ArticleDiabetes care2010
Microalbuminuria, preeclampsia, and preterm delivery in pregnant women with type 1 diabetes: results from a nationwide Danish study.
Article in Diabetes care, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- A Systematic Review and Meta-Analysis of Outcomes of Pregnancy in CKD and CKD Outcomes in Pregnancy.Clinical journal of the American Society of Nephrology : CJASN · 2015Pooled it
- Type 1 diabetes, diabetic nephropathy, and pregnancy: a systematic review and meta-study.The review of diabetic studies : RDS · 2013Pooled it
- Optimal glycemic control, pre-eclampsia, and gestational hypertension in women with type 1 diabetes in the diabetes and pre-eclampsia intervention trial.Diabetes care · 2011Trial
- The impact of obesity on pregnancy outcomes in women with type 1 and type 2 diabetes across the NSW population: A retrospective cohort study.Diabetic medicine : a journal of the British Diabetic Association · 2026Article
- Pregnancy Outcomes and Maternal Characteristics in Women with Pregestational and Gestational Diabetes: A Population-Based Study in Spain, 2016-2022.Journal of clinical medicine · 2024Article
- Intrauterine Growth Restriction Due to Gestational Diabetes: From Pathophysiology to Diagnosis and Management.Medicina (Kaunas, Lithuania) · 2023Review
- Preeclampsia: Recent Advances in Predicting, Preventing, and Managing the Maternal and Fetal Life-Threatening Condition.International journal of environmental research and public health · 2023Review
- Fetoplacental oxygen homeostasis in pregnancies with maternal diabetes mellitus and obesity.Nature reviews. Endocrinology · 2022Review
- Maternal Levels of Perfluoroalkyl Substances (PFAS) during Early Pregnancy in Relation to Preeclampsia Subtypes and Biomarkers of Preeclampsia Risk.Environmental health perspectives · 2021Article
- Preeclampsia and Glomerulonephritis: A Bidirectional Association.Current hypertension reports · 2020Review
- Pre-pregnancy kidney function and subsequent adverse pregnancy outcomes.Pregnancy hypertension · 2019Article
- Hypertensive disorders during pregnancy and 3 years after delivery in women with gestational hyperglycemia.Journal of endocrinological investigation · 2018Observational
- Association of Maternal Diabetes With Neonatal Outcomes of Very Preterm and Very Low-Birth-Weight Infants: An International Cohort Study.JAMA pediatrics · 2018Article
- Fetal Risks and Maternal Renal Complications in Pregnancy with Preexisting Chronic Glomerulonephritis.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Subclinical First Trimester Renal Abnormalities Are Associated With Preeclampsia in Normoalbuminuric Women With Type 1 Diabetes.Diabetes care · 2018Article
- Trends and racial and ethnic disparities in the prevalence of pregestational type 1 and type 2 diabetes in Northern California: 1996-2014.American journal of obstetrics and gynecology · 2017Article
- Maternal overweight and obesity and risk of pre-eclampsia in women with type 1 diabetes or type 2 diabetes.Diabetologia · 2016Article
- Article
- A best practice position statement on pregnancy in chronic kidney disease: the Italian Study Group on Kidney and Pregnancy.Journal of nephrology · 2016Review
- Diagnosis and Management of IUGR in Pregnancy Complicated by Type 1 Diabetes Mellitus.Current diabetes reports · 2016Review
Corrections and comments
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Authors and funding
8 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study the association between microalbuminuria and development of preeclampsia and preterm delivery in pregnant women with type 1 diabetes. RESEARCH DESIGN AND
methodsThis was a population-based prospective study in 846 normoalbuminuric or microalbuminuric women with type 1 diabetes without antihypertensive treatment in early pregnancy. Data were collected prospectively by one to three caregivers in each center and reported to a central registry.
resultsThe prevalence of microalbuminuria in the first trimester was 10%, median diabetes duration was 11 years, and third-trimester A1C was 6.6%. The frequencies of preeclampsia and preterm delivery before 34 weeks in the microalbuminuric group were 40 and 13%, both significantly higher than those in the normoalbuminuric group (12 and 6%, respectively, P < 0.001). After adjustments for possible confounders, significant predictors for development of preeclampsia were microalbuminuria (odds ratio 4.0 [95% CI]), nulliparity (3.1 [1.9-5.1]), and third-trimester A1C (1.3 [1.1-1.5] per 1% increase). Delivery before 34 weeks was associated with early microalbuminuria in univariate analyses, but in multivariate analyses A1C was the only significant predictor of this outcome. Preeclampsia was associated with a threefold higher risk of delivery before 34 weeks.
conclusionsThe presence of microalbuminuria in early pregnancy is associated with a fourfold increased risk of developing preeclampsia. A1C values during pregnancy are highly predictive of both preeclampsia and preterm delivery. Future research with antihypertensive treatment in normotensive, microalbuminuric pregnant women to prevent preeclampsia is proposed.
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