ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
The development of the thalamic motor learning area is regulated by Fgf8 expression.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 56 citations in OpenAlex.
- Building thalamic neuronal networks during mouse development.Frontiers in neural circuits · 2023Review
- Diencephalic organoids - A key to unraveling development, connectivity, and pathology of the human diencephalon.Frontiers in cellular neuroscience · 2023Review
- Developmental trajectories of thalamic progenitors revealed by single-cell transcriptome profiling and Shh perturbation.Cell reports · 2022Article
- Rapid and robust directed differentiation of mouse epiblast stem cells into definitive endoderm and forebrain organoids.Development (Cambridge, England) · 2022Article
- Human neural organoids: Models for developmental neurobiology and disease.Developmental biology · 2021Review
- Defining developmental diversification of diencephalon neurons through single cell gene expression profiling.Development (Cambridge, England) · 2019Article
- Radial glia fibers translate Fgf8 morphogenetic signals to generate a thalamic nuclear complex protomap in the mantle layer.Brain structure & function · 2019Article
- Development and connectivity of the habenular nuclei.Seminars in cell & developmental biology · 2018Review
- Foxg1 deletion impairs the development of the epithalamus.Molecular brain · 2018Article
- Habenular Neurogenesis in Zebrafish Is Regulated by a Hedgehog, Pax6 Proneural Gene Cascade.PloS one · 2016Article
- Gbx2 is essential for maintaining thalamic neuron identity and repressing habenular characters in the developing thalamus.Developmental biology · 2015Article
- FGF8 activates proliferation and migration in mouse post-natal oligodendrocyte progenitor cells.PloS one · 2014Article
- Wnt signal specifies the intrathalamic limit and its organizer properties by regulating Shh induction in the alar plate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Fgf signaling governs cell fate in the zebrafish pineal complex.Development (Cambridge, England) · 2013Article
- Changes in expression and secretion patterns of fibroblast growth factor 8 and Sonic Hedgehog signaling pathway molecules during murine neural stem/progenitor cell differentiation in vitro.Neural regeneration research · 2012Article
- Wnt3 and Wnt3a are required for induction of the mid-diencephalic organizer in the caudal forebrain.Neural development · 2012Article
- Fractone-associated N-sulfated heparan sulfate shows reduced quantity in BTBR T+tf/J mice: a strong model of autism.Behavioural brain research · 2012Article
- Molecular regionalization of the diencephalon.Frontiers in neuroscience · 2012Article
- Patterning and compartment formation in the diencephalon.Frontiers in neuroscience · 2012Article
- BTBR T+tf/J mice: autism-relevant behaviors and reduced fractone-associated heparan sulfate.Neuroscience and biobehavioral reviews · 2012Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Habenular nuclei play a key role in the control of motor and cognitive behavior, processing emotion, motivation, and reward values in the brain. Thus, analysis of the molecular and cellular mechanisms underlying the development and evolution of this region will contribute to a better understanding of brain function. The Fgf8 gene is expressed in the dorsal midline of the diencephalon, close to the area in which the habenular region will develop. Given that Fgf8 is an important morphogenetic signal, we decided to investigate the role of Fgf8 signaling in diencephalic development. To this end, we analyzed the effects of altered Fgf8 expression in the mouse embryo, using molecular and cellular markers. Decreasing Fgf8 activity in the diencephalon was found to be associated with dosage-dependent alterations in the epithalamus: the habenular region and pineal gland are reduced or lacking in Fgf8 hypomorphic mice. Actually, our findings indicate that Fgf8 may be the master gene for these diencephalic domains, acting as an inductive and morphogenetic regulator. Therefore, the emergence of the habenular region in vertebrates could be understood in terms of a phylogenetic territorial addition caused by de novo expression of Fgf8 in the diencephalic alar plate. This region specializes to permit the development of adaptive control of the motor function in the vertebrate brain.
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