ArticleMolecular biology of the cell2009
Bone morphogenetic protein-6 promotes cerebellar granule neurons survival by activation of the MEK/ERK/CREB pathway.
Article in Molecular biology of the cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Cordycepin mediates neuroprotection against apoptosis via ERK/CREB signaling activation in AβIbrain · 2025Article
- BMP-6 Attenuates Oxygen and Glucose Deprivation-Induced Apoptosis in Human Neural Stem Cells through Inhibiting p38 MAPK Signaling Pathway.International journal of stem cells · 2022Article
- CREB signaling activity correlates with differentiation and survival in medulloblastoma.Scientific reports · 2021Article
- The extract of concentrated growth factor enhances osteogenic activity of osteoblast through PI3K/AKT pathway and promotes bone regeneration in vivo.International journal of implant dentistry · 2021Article
- Heterochronic Developmental Shifts Underlying Squamate Cerebellar Diversity Unveil the Key Features of Amniote Cerebellogenesis.Frontiers in cell and developmental biology · 2020Article
- Adrenoceptor-stimulated inflammatory response in stress-induced serum amyloid A synthesis.Psychopharmacology · 2019Article
- p53 regulates ERK1/2/CREB cascade via a novel SASH1/MAP2K2 crosstalk to induce hyperpigmentation.Journal of cellular and molecular medicine · 2017Article
- TGF-β Family Signaling in Neural and Neuronal Differentiation, Development, and Function.Cold Spring Harbor perspectives in biology · 2017Review
- Delineating the factors and cellular mechanisms involved in the survival of cerebellar granule neurons.Cerebellum (London, England) · 2015Review
- Bone morphogenetic protein 4 (BMP-4) and epidermal growth factor (EGF) inhibit metalloproteinase-9 (MMP-9) expression in cancer cells.Oncoscience · 2015Article
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- Substantial neuroprotection against K+ deprivation-induced apoptosis in primary cerebellar granule neurons by novel dimer bis(propyl)-cognitin via the activation of VEGFR-2 signaling pathway.CNS neuroscience & therapeutics · 2013Article
- Neuroprotective activity of peripherally administered liver growth factor in a rat model of Parkinson's disease.PloS one · 2013Article
- The dynamic role of bone morphogenetic proteins in neural stem cell fate and maturation.Developmental neurobiology · 2012Review
- Influenza A virus induces interleukin-27 through cyclooxygenase-2 and protein kinase A signaling.The Journal of biological chemistry · 2012Article
- G-protein-coupled receptor 30 mediates rapid neuroprotective effects of estrogen via depression of NR2B-containing NMDA receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Nutraceutical antioxidants as novel neuroprotective agents.Molecules (Basel, Switzerland) · 2010Review
- Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells.The international journal of biochemistry & cell biology · 2010Article
- Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone morphogenetic proteins (BMPs) have been implicated in the generation and postnatal differentiation of cerebellar granule cells (CGCs). Here, we examined the eventual role of BMPs on the survival of these neurons. Lack of depolarization causes CGC death by apoptosis in vivo, a phenomenon that is mimicked in vitro by deprivation of high potassium in cultured CGCs. We have found that BMP-6, but not BMP-7, is able to block low potassium-mediated apoptosis in CGCs. The neuroprotective effect of BMP-6 is not accompanied by an increase of Smad translocation to the nucleus, suggesting that the canonical pathway is not involved. By contrast, activation of the MEK/ERK/CREB pathway by BMP-6 is necessary for its neuroprotective effect, which involves inhibition of caspase activity and an increase in Bcl-2 protein levels. Other pathways involved in the regulation of CGC survival, such as the c-Jun terminal kinase and the phosphatidylinositol 3-kinase (PI3K)-Akt/PKB, were not affected by BMP-6. Moreover, failure of BMP-7 to activate the MEK/ERK/CREB pathway could explain its inability to protect CGCs from low potassium-mediated apoptosis. Thus, this study demonstrates that BMP-6 acting through the noncanonical MEK/ERK/CREB pathway plays a crucial role on CGC survival.
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