ArticleJournal of clinical microbiology2009
Diverse characteristics of the CagA gene of Helicobacter pylori strains collected from patients from southern vietnam with gastric cancer and peptic ulcer.
Article in Journal of clinical microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- CagA toxin and risk of Helicobacter pylori-infected gastric phenotype: A meta-analysis of observational studies.PloS one · 2024Pooled it
- Role of Helicobacter pylori cagA EPIYA motif and vacA genotypes for the development of gastrointestinal diseases in Southeast Asian countries: a meta-analysis.BMC infectious diseases · 2012Pooled it
- Review
- Comparative genomics of two Vietnamese Helicobacter pylori strains, CHC155 from a non-cardia gastric cancer patient and VN1291 from a duodenal ulcer patient.Scientific reports · 2023Article
- The endemic Helicobacter pylori population in Southern Vietnam has both South East Asian and European origins.Gut pathogens · 2021Article
- H. pylori Infection and Colorectal Cancers by Anatomical Locations.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Tailor-Made Detection of Individual Phosphorylated and Non-Phosphorylated EPIYA-Motifs ofCancers · 2019Article
- Evaluating the origin and virulence of a Helicobacter pylori cagA-positive strain isolated from a non-human primate.Scientific reports · 2018Article
- Novel CagA ELISA exhibits enhanced sensitivity ofWorld journal of gastroenterology · 2017Article
- Isolation and characterization of Helicobacter pylori recovered from gastric biopsies under anaerobic conditions.Diagnostic microbiology and infectious disease · 2016Article
- Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East Asian-type Helicobacter pylori strains.BMC microbiology · 2016Article
- Helicobacter pylori and Gastric Cancer.Frontiers in medicine · 2016Article
- Helicobacter pylori Eradication in Patients with Immune Thrombocytopenic Purpura: A Review and the Role of Biogeography.Helicobacter · 2015Review
- Five year monitoring of considerable changes in tyrosine phosphorylation motifs of Helicobacter pylori cagA gene in Iran.Journal of applied genetics · 2015Article
- Article
- Helicobacter pylori infection: host immune response, implications on gene expression and microRNAs.World journal of gastroenterology · 2014Review
- Deregulation of annexin-A1 and galectin-1 expression in precancerous gastric lesions: intestinal metaplasia and gastric ulcer.Mediators of inflammation · 2014Article
- Article
- The significance of virulence factors in Helicobacter pylori.Journal of digestive diseases · 2013Review
- Chromosome painting in silico in a bacterial species reveals fine population structure.Molecular biology and evolution · 2013Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathogenesis of gastroduodenal diseases is related to the diversity of Helicobacter pylori strains. CagA-positive strains are more likely to cause gastric cancer than CagA-negative strains. Based on EPIYA (Glu-Pro-Ile-Tyr-Ala) motifs at the carboxyl terminus corresponding to phosphorylation sites, H. pylori CagA is divided into East Asian CagA and Western CagA. The former type prevails in East Asia and is more closely associated with gastric cancer. The present study used full sequences of the cagA gene and CagA protein of 22 H. pylori strains in gastric cancer and peptic ulcer patients from Southern Vietnam to make a comparison of genetic homology among Vietnamese strains and between them and other strains in East Asia. A phylogenetic tree was constructed based on full amino acid sequences of 22 Vietnamese strains in accordance with 54 references from around the world. The cagA gene was found in all Vietnamese H. pylori strains. Twenty-one of 22 (95.5%) strains belonged to the East Asian type and had similar characteristics of amino acid sequence at the carboxyl terminus to other strains from the East Asian region. From evidence of East Asian CagA and epidemiologic cancerous lesions in Vietnam, H. pylori-infected Vietnamese can be classified into a high-risk group for gastric cancer, but further studies on the interaction among environmental and virulence factors should be done. Finally, phylogenetic data support that there is a Japanese subtype in the Western CagA type.
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