ArticleJournal of neurophysiology2009
Slow spike frequency adaptation in neurons of the rat subthalamic nucleus.
Article in Journal of neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Reconciling contradictory models of subthalamic nucleus contributions to basal ganglia beta oscillations.PLoS computational biology · 2026Article
- Biophysical and Architectural Mechanisms of Subthalamic Theta under Response Conflict.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Canard-induced complex oscillations in an excitatory network.Journal of mathematical biology · 2020Article
- Distinct current modules shape cellular dynamics in model neurons.Neuroscience · 2016Article
- Distinguishing intrinsic from extrinsic factors underlying firing rate saturation in human motor units.Journal of neurophysiology · 2015Article
- Modeling multiple time scale firing rate adaptation in a neural network of local field potentials.Journal of computational neuroscience · 2015Article
- Predicting the responses of repetitively firing neurons to current noise.PLoS computational biology · 2014Article
- Effective connectivity of the subthalamic nucleus-globus pallidus network during Parkinsonian oscillations.The Journal of physiology · 2014Article
- Coherence and frequency in the reticular activating system (RAS).Sleep medicine reviews · 2013Review
- Biophysical basis of the phase response curve of subthalamic neurons with generalization to other cell types.Journal of neurophysiology · 2012Article
- Gamma band activity in the developing parafascicular nucleus.Journal of neurophysiology · 2012Article
- Gamma band activity in the reticular activating system.Frontiers in neurology · 2012Article
- Effects of persistent inward currents, accommodation, and adaptation on motor unit behavior: a simulation study.Journal of neurophysiology · 2011Article
- Cholinergic and glutamatergic agonists induce gamma frequency activity in dorsal subcoeruleus nucleus neurons.American journal of physiology. Cell physiology · 2011Article
- Cortical stimulation evokes abnormal responses in the dopamine-depleted rat basal ganglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Multiple components of ganglion cell desensitization in response to prosthetic stimulation.Journal of neural engineering · 2011Article
- Gamma band unit activity and population responses in the pedunculopontine nucleus.Journal of neurophysiology · 2010Article
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3 authors.
Funding
Abstract
Neurons of the subthalamic nucleus (STN) are very sensitive to applied currents, firing at 10-20/s during spontaneous activity, but increasing to peak firing rates of 200/s with applied currents <0.5 nA. They receive a powerful tonic excitatory input from neurons in the cerebral cortex, yet in vivo maintain an irregular firing rate only slightly higher than the autonomous firing rate seen in slices. Spike frequency adaptation acts to normalize background firing rate by removing slow trends in firing due to changes in average input. Subthalamic neurons have been previously described as showing little spike frequency adaptation, but this was based on tests using brief stimuli. We applied long-duration depolarizing current steps to STN neurons in slices and observed a very strong spike frequency adaptation with a time constant of 20 s and that recovered at a similar rate. This adaptation could return firing to near-baseline levels during prolonged current pulses that transiently drove the cells at high rates. The current responsible for adaptation was studied in voltage clamp during and after high-frequency driving of the cell and was determined to be a slowly accumulating K(+) current. This current was independent of calcium or sodium entry and could be induced with long-duration voltage steps after blockade of action potentials. In addition to the adaptation current, driven firing produced slow inactivation of the persistent Na(+) current, which also contributed to the reduced excitability of STN cells during and after driven firing.
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