ArticleGenome research2010
ProPhylER: a curated online resource for protein function and structure based on evolutionary constraint analyses.
Article in Genome research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Germline mutations of regulator of telomere elongation helicase 1, RTEL1, in Dyskeratosis congenita.Human genetics · 2013Trial
- Mechanistic insights into the deleterious roles of Nasu-Hakola disease associated TREM2 variants.Scientific reports · 2020Article
- Combining structure and genomics to understand antimicrobial resistance.Computational and structural biotechnology journal · 2020Review
- Aminode: Identification of Evolutionary Constraints in the Human Proteome.Scientific reports · 2018Article
- Pilot study of newborn screening for six lysosomal storage diseases using Tandem Mass Spectrometry.Molecular genetics and metabolism · 2016Article
- Next-generation sequencing identifies rare variants associated with Noonan syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Using the emerging Collaborative Cross to probe the immune system.Genes and immunity · 2014Article
- Assessment of computational methods for predicting the effects of missense mutations in human cancers.BMC genomics · 2013Article
- The SAAP pipeline and database: tools to analyze the impact and predict the pathogenicity of mutations.BMC genomics · 2013Article
- Human thromboxane A2 receptor genetic variants: in silico, in vitro and "in platelet" analysis.PloS one · 2013Article
- Novel insights from hybrid LacI/GalR proteins: family-wide functional attributes and biologically significant variation in transcription repression.Nucleic acids research · 2012Article
- Article
- The non-random clustering of non-synonymous substitutions and its relationship to evolutionary rate.BMC genomics · 2011Article
- A cell cycle phosphoproteome of the yeast centrosome.Science (New York, N.Y.) · 2011Article
- Fine mapping the KLK3 locus on chromosome 19q13.33 associated with prostate cancer susceptibility and PSA levels.Human genetics · 2011Article
- Improving the assessment of the outcome of nonsynonymous SNVs with a consensus deleteriousness score, Condel.American journal of human genetics · 2011Article
- ePlant and the 3D data display initiative: integrative systems biology on the world wide web.PloS one · 2011Article
- Article
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Authors and funding
6 authors.
Funding
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Abstract
ProPhylER (Protein Phylogeny and Evolutionary Rates) is a next-generation curated proteome resource that uses comparative sequence analysis to predict constraint and mutation impact for eukaryotic proteins. Its purpose is to inform any research program for which protein function and structure are relevant, by the predictive power of evolutionary constraint analyses. ProPhylER currently has nearly 9000 clusters of related proteins, including more than 200,000 sequences. It serves data via two interfaces. The "ProPhylER Interface" displays predictive analyses in sequence space; the "CrystalPainter" maps evolutionary constraints onto solved protein structures. Here we summarize ProPhylER's data content and analysis pipeline, demonstrate the use of ProPhylER's interfaces, and evaluate ProPhylER's unique regional analysis of evolutionary constraint. The high accuracy of ProPhylER's regional analysis complements the high resolution of its single-site analysis to effectively guide and inform structure-function investigations and predict the impact of polymorphisms.
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