Evidence map›Paper›PMID 19846583›Full record

ArticleBrain : a journal of neurology2010

Unilateral pedunculopontine stimulation improves falls in Parkinson's disease.

Elena Moro, Clement Hamani, Yu-Yan Poon, Thamar Al-Khairallah, Jonathan O Dostrovsky, William D Hutchison, Andres M Lozano

Registry-linked trialAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Brain : a journal of neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06585618 (Multicenter Pediatric Deep Brain Stimulation Registry), which is not on this map. Cited by 173 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
173citing papers in PubMed, 5 pooled it
19.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06585618 recruitingnot on this mapstarted 2024, after this paper: background citation

Multicenter Pediatric Deep Brain Stimulation Registry

TypeobservationalSponsorBoston Children's HospitalRan2024 to 2029Enrolled100ConditionsDystonia, Epilepsy in Children, Cerebral Palsy, Tourette Syndrome
3 · Its place in the literature

Who cites it

173 citing papers in PubMed, 5 syntheses or guidelines pooled it, 412 citations in OpenAlex.

  1. Pooled it
  2. Interventions for preventing falls in Parkinson's disease.The Cochrane database of systematic reviews · 2022
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  17. What is new in Freezing of Gait?Journal of neurology · 2026
    Review
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113 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Elena MoroDivision of Neurosurgery, 4-447 Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, M5T 2S8 Canada.
Clement Hamani
Yu-Yan Poon
Thamar Al-Khairallah
Jonathan O Dostrovsky
William D Hutchison
Andres M Lozano
University of Toronto · CAUniversity Health Network · CAToronto Western Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postural instability and falls are a major source of disability in patients with advanced Parkinson's disease. These problems are currently not well addressed by either pharmacotherapy nor by subthalamic nucleus deep-brain stimulation surgery. The neuroanatomical substrates of posture and gait are poorly understood but a number of important observations suggest a major role for the pedunculopontine nucleus and adjacent areas in the brainstem. We conducted a double-blinded evaluation of unilateral pedunculopontine nucleus deep-brain stimulation in a pilot study in six advanced Parkinson's disease patients with significant gait and postural abnormalities. There was no significant difference in the double-blinded on versus off stimulation Unified Parkinson's Disease Rating Scale motor scores after 3 or 12 months of continuous stimulation and no improvements in the Unified Parkinson's Disease Rating Scale part III scores compared to baseline. In contrast, patients reported a significant reduction in falls in the on and off medication states both at 3 and 12 months after pedunculopontine nucleus deep-brain stimulation as captured in the Unified Parkinson's Disease Rating Scale part II scores. Our results suggest that pedunculopontine nucleus deep-brain stimulation may be effective in preventing falls in patients with advanced Parkinson's disease but that further evaluation of this procedure is required.

Indexed as

Accidental FallsAgedDeep Brain StimulationDouble-Blind MethodFemaleHumansMaleMiddle AgedParkinson DiseasePedunculopontine Tegmental NucleusPilot ProjectsPostural Balance

Identifiers

PMID19846583
OpenAlexW2004329345

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.