ArticleProceedings. Biological sciences2010
History-dependent properties of skeletal muscle myofibrils contracting along the ascending limb of the force-length relationship.
Article in Proceedings. Biological sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- The Contraction Modalities in a Stretch-Shortening Cycle in Animals and Single Joint Movements in Humans: A Systematic Review.Journal of sports science & medicine · 2019Pooled it
- A "thermodynamic" model of synergistic interaction of human elbow flexor muscles during simultaneous change in their length and force.Frontiers in physiology · 2026Article
- The distinctive mechanical and structural signatures of residual force enhancement in myofibers.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Modifiability of residual force depression in single muscle fibers following uphill and downhill training in rats.Physiological reports · 2021Article
- Sarcomere Length Nonuniformity and Force Regulation in Myofibrils and Sarcomeres.Biophysical journal · 2020Review
- Force enhancement after stretch of isolated myofibrils is increased by sarcomere length non-uniformities.Scientific reports · 2020Article
- Sarcomere length non-uniformities dictate force production along the descending limb of the force-length relation.Proceedings. Biological sciences · 2020Article
- Current Understanding of Residual Force Enhancement: Cross-Bridge Component and Non-Cross-Bridge Component.International journal of molecular sciences · 2019Review
- The multiple roles of titin in muscle contraction and force production.Biophysical reviews · 2018Review
- Basic science and clinical use of eccentric contractions: History and uncertainties.Journal of sport and health science · 2018Review
- Titin-mediated thick filament activation stabilizes myofibrils on the descending limb of their force-length relationship.Journal of sport and health science · 2018Article
- Residual force enhancement is regulated by titin in skeletal and cardiac myofibrils.The Journal of physiology · 2017Article
- Physiological Mechanisms of Eccentric Contraction and Its Applications: A Role for the Giant Titin Protein.Frontiers in physiology · 2017Review
- The increase in non-cross-bridge forces after stretch of activated striated muscle is related to titin isoforms.American journal of physiology. Cell physiology · 2016Article
- A new experimental model for force enhancement: steady-state and transient observations of the Drosophila jump muscle.American journal of physiology. Cell physiology · 2015Article
- Residual force depression in single sarcomeres is abolished by MgADP-induced activation.Scientific reports · 2015Article
- Poorly understood aspects of striated muscle contraction.BioMed research international · 2015Review
- Arginylation of myosin heavy chain regulates skeletal muscle strength.Cell reports · 2014Article
- A new experimental model to study force depression: the Drosophila jump muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Force enhancement in lengthening contractions of cat soleus muscle in situ: transient and steady-state aspects.Physiological reports · 2013Article
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3 authors.
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Abstract
There is a history dependence of skeletal muscle contraction: stretching activated muscles induces a long-lasting force enhancement, while shortening activated muscles induces a long-lasting force depression. These history-dependent properties cannot be explained by the current model of muscle contraction, and its mechanism is unknown. The purposes of this study were (i) to evaluate if force enhancement and force depression are present at short lengths (the ascending limb of the force-length (FL) relationship), (ii) to evaluate if the history-dependent properties are associated with sarcomere length (SL) non-uniformity and (iii) to determine the effects of cross-bridge (de)activation on force depression. Rabbit psoas myofibrils were isolated and attached between two microneedles for force measurements. Images of the myofibrils were projected onto a linear photodiode array for measurements of SL. Myofibrils were activated by either Ca(2+) or MgADP; the latter induces cross-bridge attachment to actin independently of Ca(2+). Activated myofibrils were subjected to three stretches or shortenings (approx. 4% SL at approx. 0.07 microm s(-1) sarcomere(-1)) along the ascending limb of the FL relationship separated by periods (approx. 5 s) of isometric contraction. Force after stretch was higher than force after shortening at similar SLs. The differences in force could not be explained by SL non-uniformity. The FL relationship produced by Ca(2+)- and MgADP-activated myofibrils were similar in stretch experiments, but after shortening MgADP activation produced forces that were higher than Ca(2+) activation. Since MgADP induces the formation of strongly bound cross-bridges, this result suggests that force depression following shortening is associated with cross-bridge deactivation.
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