ReviewCurrent opinion in genetics & development2009
Nuclear organization in the 3D space of the nucleus - cause or consequence?
Review in Current opinion in genetics & development, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- Review
- Three-dimensional isotropic imaging of live suspension cells enabled by droplet microvortices.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Deciphering Precise Gene Transcriptional Expression Using gwINTACT in Tomato.Frontiers in plant science · 2022Article
- Repetitive Elements in Humans.International journal of molecular sciences · 2021Review
- Chromatin Landscaping At Mitotic Exit Orchestrates Genome Function.Frontiers in genetics · 2020Review
- Non-Coding RNAs and their Integrated Networks.Journal of integrative bioinformatics · 2019Review
- The Cajal Body Protein WRAP53β Prepares the Scene for Repair of DNA Double-Strand Breaks by Regulating Local Ubiquitination.Frontiers in molecular biosciences · 2019Review
- Optical computed tomography for spatially isotropic four-dimensional imaging of live single cells.Science advances · 2017Article
- The multidimensional mechanisms of long noncoding RNA function.Genome biology · 2017Review
- 3Disease Browser: A Web server for integrating 3D genome and disease-associated chromosome rearrangement data.Scientific reports · 2016Article
- Article
- miRNAs regulated by estrogens, tamoxifen, and endocrine disruptors and their downstream gene targets.Molecular and cellular endocrinology · 2015Review
- New quantitative approaches reveal the spatial preference of nuclear compartments in mammalian fibroblasts.Journal of the Royal Society, Interface · 2015Article
- Non-coding RNA: a new frontier in regulatory biology.National science review · 2014Article
- Long-range genomic interactions epigenetically regulate the expression of a cytokine receptor.EMBO reports · 2012Article
- Article
- Biogenesis and function of nuclear bodies.Trends in genetics : TIG · 2011Review
- Article
- Mapping of the nuclear matrix-bound chromatin hubs by a new M3C experimental procedure.Nucleic acids research · 2010Article
- High-resolution whole-genome sequencing reveals that specific chromatin domains from most human chromosomes associate with nucleoli.Molecular biology of the cell · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Recent evidence suggests that dynamic three-dimensional genomic interactions in the nucleus exert critical roles in regulated gene expression. Here, we review a series of recent paradigm-shifting experiments that highlight the existence of specific gene networks within the self-organizing space of the nucleus. These gene networks, evidenced by long-range intrachromosomal and interchromosomal interactions, can be considered as the cause or consequence of regulatory biological programs. Changes in nuclear architecture are a hallmark of laminopathies and likely potentiate genome rearrangements critical for tumor progression, in addition to potential vital contribution of noncoding RNAs and DNA repeats. It is virtually certain that we will witness an ever-increasing rate of discoveries that uncover new roles of nuclear architecture in transcription, DNA damage/repair, aging, and disease.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.