Evidence map›Paper›PMID 19846067›Full record

ArticleBiological psychiatry2010

A genomewide association study of citalopram response in major depressive disorder.

Holly A Garriock, Jeffrey B Kraft, Stanley I Shyn, Eric J Peters, Jennifer S Yokoyama, Gregory D Jenkins, Megan S Reinalda, Susan L Slager, Patrick J McGrath, Steven P Hamilton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed, 14 pooled it
15.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 14 syntheses or guidelines pooled it, 291 citations in OpenAlex.

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86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Holly A GarriockDepartment of Psychiatry and Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94143-0984, USA.
Jeffrey B Kraft
Stanley I Shyn
Eric J Peters
Jennifer S Yokoyama
Gregory D Jenkins
Megan S Reinalda
Susan L Slager
Patrick J McGrath
Steven P Hamilton
University of California, San Francisco · USMayo Clinic · USColumbia University · US

Funding

PREDOCTORAL TRAINING CONSORTIUM IN AFFECTIVE SCIENCET32MH020006 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI GROSS, JAMES J, JOHNSON, SHERI L · 1998 to 2018
$5.9M
PROGRAM FOR MINORITY RESEARCH TRAINING IN PSYCHIATRY (PMT32MH019126 · NIMH · AMERICAN PSYCHIATRIC INST FOR RES &EDUC · PI REGIER, DARREL A · 1989 to 2009
$5.3M
TRAINING THE NEXT GENERATION OF MENTAL HEALTH RESEARCHERSR25MH060482 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DANIEL H MATHALON, Susan M. Voglmaier · 2000 to 2026
$5.2M
Pharmacogenomics of Antidepressant ResponseR01MH072802 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HAMILTON, STEVEN P. · 2005 to 2008
$4.6M
MOLECULAR APPROACHES TO MENTAL ILLNESST32MH019552 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BARONDES, SAMUEL H. · 1992 to 2006
$1.4M
Role of OPRM1 in an Antidepressant Response and Major Depressive DisorderF32MH082562 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GARRIOCK, HOLLY A · 2008 to 2008
$51k
TREATMENT RESISTANT DEPRESSION-278990003N01MH090003 · NIMH · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · 1999 to 2003
–
Howard Hughes Medical InstituteNIMH NIH HHS F32 MH082562NIMH NIH HHS F32 MH082562-01A1NIMH NIH HHS MH072802NIMH NIH HHS N01 MH090003NIMH NIH HHS R01 MH072802NIMH NIH HHS R25 MH060482NIMH NIH HHS R25 MH060482-08NIMH NIH HHS T32 MH019126NIMH NIH HHS T32 MH019552NIMH NIH HHS T32 MH020006NIMH NIH HHS T32 MH19126-19NIMH NIH HHS T32 MH19552-11
6 · The paper itself

Abstract

backgroundAntidepressant response is likely influenced by genetic constitution, but the actual genes involved have yet to be determined. We have carried out a genomewide association study to determine whether common DNA variation influences antidepressant response.

methodsOur sample is derived from Level 1 participants in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, all treated with citalopram. Association for the response phenotype included 883 responders and 608 nonresponders. For the remission phenotype, 743 subjects that achieved remission were compared with 608 nonresponders. We used a subset of single nucleotide polymorphisms (SNPs; n = 430,198) from the Affymetrix 500K and 5.0 Human SNP Arrays, and association analysis was carried out after correcting for population stratification.

resultsWe identified three SNPs associated with response with p values less than 1 x 10(-5) near the UBE3C gene (rs6966038, p = 4.65 x 10(-7)), another 100 kb away from BMP7 (rs6127921, p = 3.45 x 10(-6)), and a third that is intronic in the RORA gene (rs809736, p = 8.19 x 10(-6)). These same SNPs were also associated with remission. Thirty-nine additional SNPs are of interest with p values < or = .0001 for the response and remission phenotypes.

conclusionsAlthough the findings reported here do not meet a genomewide threshold for significance, the regions identified from this study provide targets for independent replication and novel pathways to investigate mechanisms of antidepressant response. This study was not placebo controlled, making it possible that we are also observing associations to nonspecific aspects of drug treatment of depression.

Indexed as

Genome-Wide Association StudyPharmacogeneticsAntidepressive Agents, Second-GenerationBone Morphogenetic Protein 7CitalopramCluster AnalysisFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansMajor Depressive DisorderMaleNuclear Receptor Subfamily 1, Group F, Member 1Odds RatioPolymorphism, Single NucleotideAntidepressive Agents, Second-GenerationBMP7 protein, humanBone Morphogenetic Protein 7CitalopramNuclear Receptor Subfamily 1, Group F, Member 1RORA protein, humanUBE2N protein, humanUbiquitin-Conjugating Enzymes

Identifiers

PMID19846067
PMCPMC2794921
OpenAlexW2059483509

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.