ArticleSource code for biology and medicine2009
ParaHaplo: A program package for haplotype-based whole-genome association study using parallel computing.
Article in Source code for biology and medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Genotype Value Decomposition: Simple Methods for the Computation of Kernel Statistics.Advanced genetics (Hoboken, N.J.) · 2022Article
- ParaHaplo 3.0: A program package for imputation and a haplotype-based whole-genome association study using hybrid parallel computing.Source code for biology and medicine · 2011Article
- ParaHaplo 2.0: a program package for haplotype-estimation and haplotype-based whole-genome association study using parallel computing.Source code for biology and medicine · 2010Article
- ParallABEL: an R library for generalized parallelization of genome-wide association studies.BMC bioinformatics · 2010Article
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Authors and funding
2 authors.
Funding
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Abstract
backgroundSince more than a million single-nucleotide polymorphisms (SNPs) are analyzed in any given genome-wide association study (GWAS), performing multiple comparisons can be problematic. To cope with multiple-comparison problems in GWAS, haplotype-based algorithms were developed to correct for multiple comparisons at multiple SNP loci in linkage disequilibrium. A permutation test can also control problems inherent in multiple testing; however, both the calculation of exact probability and the execution of permutation tests are time-consuming. Faster methods for calculating exact probabilities and executing permutation tests are required.
methodsWe developed a set of computer programs for the parallel computation of accurate P-values in haplotype-based GWAS. Our program, ParaHaplo, is intended for workstation clusters using the Intel Message Passing Interface (MPI). We compared the performance of our algorithm to that of the regular permutation test on JPT and CHB of HapMap.
resultsParaHaplo can detect smaller differences between 2 populations than SNP-based GWAS. We also found that parallel-computing techniques made ParaHaplo 100-fold faster than a non-parallel version of the program.
conclusionParaHaplo is a useful tool in conducting haplotype-based GWAS. Since the data sizes of such projects continue to increase, the use of fast computations with parallel computing--such as that used in ParaHaplo--will become increasingly important. The executable binaries and program sources of ParaHaplo are available at the following address: http://sourceforge.jp/projects/parallelgwas/?_sl=1.
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