ArticleBritish journal of pharmacology2009
Further pharmacological characterization of 5-HT(2C) receptor agonist-induced inhibition of 5-HT neuronal activity in the dorsal raphe nucleus in vivo.
Article in British journal of pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 49 citations in OpenAlex.
- Lorcaserin Alters Serotonin and Noradrenaline Tissue Content and Their Interaction With Dopamine in the Rat Brain.Frontiers in pharmacology · 2020Article
- Preferential modulation of the lateral habenula activity by serotonin-2A rather than -2C receptors: Electrophysiological and neuroanatomical evidence.CNS neuroscience & therapeutics · 2018Article
- Positive regulation of raphe serotonin neurons by serotonin 2B receptors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Behavioral, pharmacological and neuroanatomical analysis of serotonin 2C receptor agonism on maternal behavior in rats.Psychoneuroendocrinology · 2016Article
- Dorsal raphe 5-HT(2C) receptor and GABA networks regulate anxiety produced by cocaine withdrawal.Neuropharmacology · 2015Article
- Central serotonin-2A (5-HT2A) receptor dysfunction in depression and epilepsy: the missing link?Frontiers in pharmacology · 2015Review
- Effect of genetic and pharmacological blockade of GABA receptors on the 5-HT2C receptor function during stress.Journal of neurochemistry · 2014Article
- Gq/5-HT2c receptor signals activate a local GABAergic inhibitory feedback circuit to modulate serotonergic firing and anxiety in mice.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Serotonin (2C) receptor regulation of cocaine-induced conditioned place preference and locomotor sensitization.Behavioural brain research · 2013Article
- Reduced activity at the 5-HT(2C) receptor enhances reversal learning by decreasing the influence of previously non-rewarded associations.Psychopharmacology · 2012Article
- Differences in the locomotor-activating effects of indirect serotonin agonists in habituated and non-habituated rats.Pharmacology, biochemistry, and behavior · 2012Article
- Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens.Neuropharmacology · 2011Review
- Control of hippocampal theta rhythm by serotonin: role of 5-HT2c receptors.Neuropharmacology · 2011Article
- Deletion of CB2 cannabinoid receptor induces schizophrenia-related behaviors in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- A pronociceptive role for the 5-HT2 receptor on spinal nociceptive transmission: an in vivo electrophysiological study in the rat.Brain research · 2011Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
background and purposeRecent experiments using non-selective 5-hydroxytryptamine (5-HT)(2C) receptor agonists including WAY 161503 suggested that midbrain 5-HT neurones are under the inhibitory control of 5-HT(2C) receptors, acting via neighbouring gamma-aminobutyric acid (GABA) neurones. The present study extended this pharmacological characterization by comparing the actions of WAY 161503 with the 5-HT(2C) receptor agonists, Ro 60-0275 and 1-(3-chlorophenyl) piperazine (mCPP), as well as the non-selective 5-HT agonist lysergic acid diethylamide (LSD) and the 5-HT releasing agent 3,4-methylenedioxymethamphetamine (MDMA). EXPERIMENTAL APPROACH: 5-HT neuronal activity was measured in the dorsal raphe nucleus (DRN) using extracellular recordings in anaesthetized rats. The activity of DRN GABA neurones was assessed using double-label immunohistochemical measurements of Fos and glutamate decarboxylase (GAD). KEY
resultsRo 60-0175, like WAY 161503, inhibited 5-HT neurone firing, and the 5-HT(2C) antagonist SB 242084 reversed this effect. mCPP also inhibited 5-HT neurone firing ( approximately 60% neurones) in a SB 242084-reversible manner. LSD inhibited 5-HT neurone firing; however, this effect was not altered by either SB 242084 or the 5-HT(2A/C) receptor antagonist ritanserin but was reversed by the 5-HT(1A) receptor antagonist WAY 100635. Similarly, MDMA inhibited 5-HT neurone firing in a manner reversible by WAY 100635, but not SB 242084 or ritanserin. Finally, both Ro 60-0275 and mCPP, like WAY 161503, increased Fos expression in GAD-positive DRN neurones. CONCLUSIONS AND IMPLICATIONS: These data strengthen the hypothesis that midbrain 5-HT neurones are under the inhibitory control of 5-HT(2C) receptors, and suggest that the 5-HT(2C) agonists Ro 60-0175, mCPP and WAY 161503, but not LSD or MDMA, are useful probes of the mechanism(s) involved.
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