ArticleAccounts of chemical research2010
Water in the half shell: structure of water, focusing on angular structure and solvation.
Article in Accounts of chemical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 81 citations in OpenAlex.
- Unravelling Water Anomalies Using a Percolation Approach.ACS omega · 2026Article
- Effect of Three Bleaching Protocols on Tooth Discoloration Caused by Hemoglobin.Frontiers in dentistry · 2024Article
- Using Different Surface Energy Models to Assess the Interactions between Antiviral Coating Films and phi6 Model Virus.Journal of functional biomaterials · 2023Article
- Comparative Effects of Three Bleaching Techniques on Tooth Discoloration Caused by Tea.Frontiers in dentistry · 2023Article
- Molecular mechanisms from reaction coordinate graph enabled multidimensional free energies illustrated on water dimer hydrogen bonding.Journal of computational chemistry · 2022Article
- Arrangement of Hydrogen Bonds in Aqueous Solutions of Different Globular Proteins.International journal of molecular sciences · 2022Article
- Water Activity Prediction in Sugar and Polyol Systems Using Theoretical Molecular Descriptors.International journal of molecular sciences · 2021Article
- Review
- Characterizing key features in the formation of ice and gas hydrate systems.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2019Article
- Unbiased Atomistic Insight into the Mechanisms and Solvent Role for Globular Protein Dimer Dissociation.The journal of physical chemistry. B · 2019Article
- Solvation Structure and Thermodynamic Mapping (SSTMap): An Open-Source, Flexible Package for the Analysis of Water in Molecular Dynamics Trajectories.Journal of chemical theory and computation · 2018Article
- Do guanidinium and tetrapropylammonium ions specifically interact with aromatic amino acid side chains?Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Enthalpic Breakdown of Water Structure on Protein Active-Site Surfaces.The journal of physical chemistry. B · 2016Article
- Molecular Shape and the Hydrophobic Effect.Annual review of physical chemistry · 2016Review
- Characterization of the Local Structure in Liquid Water by Various Order Parameters.The journal of physical chemistry. B · 2015Article
- Structure and dynamics of urea/water mixtures investigated by vibrational spectroscopy and molecular dynamics simulation.The journal of physical chemistry. B · 2013Article
- Noncovalent Interaction Analysis in Fluctuating Environments.Journal of chemical theory and computation · 2013Article
- Solute's perspective on how trimethylamine oxide, urea, and guanidine hydrochloride affect water's hydrogen bonding ability.The journal of physical chemistry. B · 2012Article
- Temperature dependence of water interactions with the amide carbonyls of α-helices.Biochemistry · 2012Article
- Site-specific hydration dynamics of globular proteins and the role of constrained water in solvent exchange with amphiphilic cosolvents.The journal of physical chemistry. B · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Water is a highly polar molecule, consisting of a very electronegative atom, oxygen, bonded to two weakly electropositive hydrogen atoms with two lone pairs of electrons. These features give water remarkable physical properties, some of which are anomalous, such as its lower density in the solid phase compared with the liquid phase. Its ability to serve as both a hydrogen bond donor and hydrogen bond acceptor governs its role as a solvent, a role that is of central interest for biological chemists. In this Account, we focus on water's properties as a solvent. Water dissolves a vast range of solutes with solubilities that range over 10 orders of magnitude. Differences in solubility define the fundamental dichotomy between polar, or hydrophilic, solutes and apolar, or hydrophobic, solutes. This important distinction plays a large part in the structure, stability, and function of biological macromolecules. The strength of hydrogen bonding depends on the H-O...O H-bond angle, and the angular distribution is bimodal. Changes in the width and frequency of infrared spectral lines and in the heat capacity of the solution provide a measure of the changes in the strength and distribution of angles of the hydrogen bonds. Polar solutes and inorganic ions increase the population of bent hydrogen bonds at the expense of the more linear population, while apolar solutes or groups have the opposite effect. We examine how protein denaturants might alter the solvation behavior of water. Urea has very little effect on water's hydrogen bond network, while guanidinium ions promote more linear hydrogen bonds. These results point to fundamental differences in the protein denaturation mechanisms of these molecules. We also suggest a mechanism of action for antifreeze (or thermal hysteresis) proteins: ordering of water around the surface of these proteins prior to freezing appears to interfere with ice formation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.