Evidence map›Paper›PMID 19844813›Full record

ReviewMolecular neurobiology2009

Determining the neurotransmitter concentration profile at active synapses.

Annalisa Scimemi, Marco Beato

Open access · hybridAbstract readReview
In one paragraph

Review in Molecular neurobiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 149 citations in OpenAlex.

  1. Article
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  3. Review
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  8. CaActa physiologica (Oxford, England) · 2025
    Article
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  11. Article
  12. Review
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  16. Article
  17. Model of the HVC neural network as a song motor in zebra finch.Frontiers in computational neuroscience · 2024
    Article
  18. Article
  19. Article
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 3 countries.

Annalisa ScimemiSynaptic Physiology Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-3701, USA. scimemia@ninds.nih.gov
Marco Beato
National Institutes of Health · USUCL Australia · AU

Funding

Dynamics Of Excitatory Synaptic Transmission In The HippocampusZIANS002986 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI DIAMOND, JEFFREY S · 2009 to 2013
$2.1M
Dynamics Of Excitatory Synaptic Transmission In The HippocampusZ01NS002986 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI DIAMOND, JEFFREY S · 2000 to 2008
$808k
Intramural NIH HHS Z01 NS002986Wellcome TrustWellcome Trust 07662/Z/05/A
6 · The paper itself

Abstract

Establishing the temporal and concentration profiles of neurotransmitters during synaptic release is an essential step towards understanding the basic properties of inter-neuronal communication in the central nervous system. A variety of ingenious attempts has been made to gain insights into this process, but the general inaccessibility of central synapses, intrinsic limitations of the techniques used, and natural variety of different synaptic environments have hindered a comprehensive description of this fundamental phenomenon. Here, we describe a number of experimental and theoretical findings that has been instrumental for advancing our knowledge of various features of neurotransmitter release, as well as newly developed tools that could overcome some limits of traditional pharmacological approaches and bring new impetus to the description of the complex mechanisms of synaptic transmission.

Indexed as

AlgorithmsAnimalsComputer SimulationExocytosisModels, NeurologicalNeuronsNeurotransmitter AgentsPresynaptic TerminalsSynaptic TransmissionSynaptic VesiclesNeurotransmitter Agents

Identifiers

PMID19844813
PMCPMC2777263
OpenAlexW2122912327

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.