ArticleJournal of clinical immunology2010
Proinflammatory cytokine gene polymorphisms in irritable bowel syndrome.
Article in Journal of clinical immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Research on functional constipation with anxiety or depression: a bibliometric analysis.Frontiers in psychiatry · 2025Pooled it
- Review
- Ethnic differences in genetic polymorphism associated with irritable bowel syndrome.World journal of gastroenterology · 2020Review
- Pressure management as an occupational stress risk factor in irritable bowel syndrome: A cross-sectional study.Medicine · 2018Article
- Article
- High-sensitive C-Reactive Protein as a Marker for Inflammation in Irritable Bowel Syndrome.Journal of clinical gastroenterology · 2016Article
- Significance of IL-1RA Polymorphism in Iranian Patients with Inflammatory Bowel Disease.Digestive diseases and sciences · 2015Article
- Genetic polymorphism in pathogenesis of irritable bowel syndrome.World journal of gastroenterology · 2014Review
- Irritable bowel syndrome: a disease still searching for pathogenesis, diagnosis and therapy.World journal of gastroenterology · 2014Review
- Molecular basis of the irritable bowel syndrome.World journal of gastroenterology · 2014Review
- Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome.American journal of physiology. Gastrointestinal and liver physiology · 2013Review
- Host immune response determines visceral hyperalgesia in a rat model of post-inflammatory irritable bowel syndrome.Journal of gastroenterology · 2013Article
- Investigation of interleukin-10 promoter polymorphisms and interleukin-10 levels in children with irritable bowel syndrome.Gut and liver · 2013Article
- Identifying and testing candidate genetic polymorphisms in irritable bowel syndrome: association with TNFSF15 and tumor necrosis factor-αAnnals of gastroenterology · 2013Article
- Nature and nurture of human pain.Scientifica · 2013Review
- Novel insights which may translate into treatments for irritable bowel syndrome.Frontiers in pharmacology · 2013Article
- Interleukin-8 and -10 gene polymorphisms in irritable bowel syndrome.Molecular biology reports · 2012Article
- Findings related to IL-8 and IL-10 gene polymorphisms in a Mexican patient population with irritable bowel syndrome infected with Blastocystis.Parasitology research · 2012Article
- Associations between pro- and anti-inflammatory cytokine genes and breast pain in women prior to breast cancer surgery.The journal of pain · 2012Article
- Salmeterol attenuates the inflammatory response in asthma and decreases the pro-inflammatory cytokine secretion of dendritic cells.Cellular & molecular immunology · 2012Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIrritable bowel syndrome (IBS) is a multifactorial functional gastrointestinal disorder, characterized by recurrent abdominal pain and altered bowel habits. Proinflammatory cytokines can play an important role in intestinal inflammation, while their production is under genetic control.
methodsThis study was performed in a group of patients with IBS to analyze the genotype frequencies of a number polymorphic genes coding for proinflammatory cytokine (interleukin-6 (IL), tumor necrosis factor-alpha (TNF-alpha), and IL-1 group). Using polymerase chain reaction with sequence-specific primers method, the cytokine genes were amplified, and alleles and genotypes of 71 patients with IBS were detected on gel electrophoresis, and the results were compared with healthy control subjects.
resultsResults of the analyzed data showed that the frequencies IL-1R C allele at position Pst-I 1970 (P = 0.017), IL-6 G allele at position -174 (P = 0.002), and TNF-alpha G allele at position -238 (P < 0.001) in the patient group were significantly higher than the control group. IL-6 GG genotype (-174) and TNF-alpha GG genotype (-238) in the patient group were also significantly overrepresented (P < 0.001), while IL-6 CG genotype (-174) and TNF-alpha GA genotype (-238) were significantly decreased in the patients with IBS (P < 0.001). The frequencies of IL-6 (-174, nt565) GG haplotype and TNF-alpha (-308, -238) GG haplotype were also significantly higher in the patient group (P < 0.001), whereas the frequencies of the haplotypes IL-6 CG and TNF-alpha GA were significantly decreased in the patients with IBS (P < 0.001).
conclusionIL-6 and TNF-alpha proinflammatory cytokine gene polymorphisms could change individual susceptibility to IBS and might have a role in pathophysiology of disease.
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