ArticleIntensive care medicine2010
Value of procalcitonin for diagnosis of early onset pneumonia in hypothermia-treated cardiac arrest patients.
Article in Intensive care medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Is therapeutic hypothermia beneficial for pediatric patients with traumatic brain injury? A meta-analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2013Pooled it
- Can Biomarkers Correctly Predict Ventilator-associated Pneumonia in Patients Treated With Targeted Temperature Management After Cardiac Arrest? An Exploratory Study of the Multicenter Randomized Antibiotic (ANTHARTIC) Study.Critical care explorations · 2024Trial
- Optimizing infection management after cardiac arrest: addressing diagnostic uncertainty and therapeutic dilemmas-a narrative review.Journal of intensive care · 2026Review
- Incidence and Risk Factors of Ventilator-Associated Pneumonia in Cardiac Arrest in Patients With Selective Digestive Decontamination.Critical care research and practice · 2025Article
- Microbiological features of drowning-associated pneumonia: a systematic review and meta-analysis.Annals of intensive care · 2024Review
- Early mNGS testing for diagnose and prognostic prediction of early onset pneumonia among in-hospital cardiac arrest patients undergoing extracorporeal cardiopulmonary resuscitation.Frontiers in cellular and infection microbiology · 2024Article
- Association between C-reactive protein-to-albumin ratio and 6-month mortality in out-of-hospital cardiac arrest.Acute and critical care · 2022Article
- Impact on antimicrobial consumption of procalcitonin-guided antibiotic therapy for pneumonia/pneumonitis associated with aspiration in comatose mechanically ventilated patients: a multicenter, randomized controlled study.Annals of intensive care · 2021Article
- Is Procalcitonin a Marker of Neurologic Outcome or Early Infection in Patients Treated with Targeted Temperature Management?Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2020Article
- Prognostic value of the delta neutrophil index in pediatric cardiac arrest.Scientific reports · 2020Article
- Early diagnostic value of serum procalcitonin levels for catheter-related blood stream infection in first-ever acute ischemic stroke patients.BMC neurology · 2020Article
- Diagnostic Accuracy of Procalcitonin for Early Aspiration Pneumonia in Critically Ill Patients with Coma: A Prospective Study.Neurocritical care · 2019Observational
- Observational
- Plasma procalcitonin concentrations predict organ dysfunction and outcome in dogs with sepsis.BMC veterinary research · 2018Article
- Do we need new trials of procalcitonin-guided antibiotic therapy?Critical care (London, England) · 2018Article
- Biomarker kinetics in the prediction of VAP diagnosis: results from the BioVAP study.Annals of intensive care · 2016Article
- ACS network-based implementation of therapeutic hypothermia for the treatment of comatose out-of-hospital cardiac arrest survivors improves clinical outcomes: the first European experience.Scandinavian journal of trauma, resuscitation and emergency medicine · 2013Article
- Plasma thioredoxin levels during post-cardiac arrest syndrome: relationship with severity and outcome.Critical care (London, England) · 2013Article
- Biomarker-guided antibiotic therapy in adult critically ill patients: a critical review.Annals of intensive care · 2012Article
- The sensitivity of neutrophil CD64 expression as a biomarker of bacterial infection is low in critically ill patients.Intensive care medicine · 2012Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEarly onset pneumonia is frequently reported after cardiac arrest, despite the fact that therapeutic hypothermia and post-resuscitation disease manifestations make it difficult to diagnose. We aimed to assess the ability of serum procalcitonin (PCT) measurements to help diagnose pneumonia in this setting.
methodsRetrospective study of consecutive patients admitted to a single academic medical intensive care unit (ICU) for successfully resuscitated cardiac arrest (July 2006-March 2008). All patient files were reviewed to assess the development of pneumonia during the first 5 days of ICU stay. Serum PCT was measured at admission, days (D) 1, 2 and 3.
resultsAmong 132 patients included, pneumonia was diagnosed in 86, and antibiotics were initiated in 115 patients during the first 5 days. PCT was significantly higher in patients with pneumonia at D1 (4.58 vs. 1.03 ng/ml, p = 0.017), D2 (3.76 vs. 0.73, p = 0.002) and D3 (3.76 vs. 0.73, p = 0.046). Areas under the ROC curves were 0.59 at admission, 0.64 at D1, 0.68 at D2 and 0.63 at D3. Using a threshold of 0.5 ng/ml, negative predictive values were 39% at admission, 42% at D1 and 52% at D2, whereas positive predictive values were 72, 68 and 70%, respectively. Patients with post-resuscitation shock (n = 66) had significantly higher PCT levels than vasopressor-free patients from D1 to D3.
conclusionsThe diagnostic value of PCT is poor after cardiac arrest and should not be performed to assess early onset pneumonia. The post-resuscitation disease itself could play a major role in this lack of specificity and predictive value.
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Registered trials
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