Evidence map›Paper›PMID 19844610›Full record

ArticleMathematical modelling of natural phenomena2009

The Intersection of Theory and Application in Elucidating Pattern Formation in Developmental Biology.

Hans G Othmer, Kevin Painter, David Umulis, Chuan Xue

Open access · bronzeAbstract read
In one paragraph

Article in Mathematical modelling of natural phenomena, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 76 citations in OpenAlex.

  1. Article
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  5. Review
  6. Bespoke Turing Systems.Bulletin of mathematical biology · 2021
    Article
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  16. Review
  17. Predicting the spatiotemporal dynamics of hair follicle patterns in the developing mouse.Proceedings of the National Academy of Sciences of the United States of America · 2014
    Article
  18. Quantification of variability in trichome patterns.Frontiers in plant science · 2014
    Review
  19. Mechanisms of scaling in pattern formation.Development (Cambridge, England) · 2013
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Hans G OthmerSchool of Mathematics and Digital Technology Center, University of Minnesota, Minneapolis, MN 55455 USA.
Kevin Painter
David Umulis
Chuan Xue
Maxwell Institute for Mathematical Sciences · GBPurdue University West Lafayette · USThe Ohio State University · USUniversity of Minnesota · US

Funding

DYNAMIC PATTERN IN CHEMICALLY-REACTING SYSTEMSR01GM029123 · NIGMS · UNIVERSITY OF UTAH · PI OTHMER, HANS G · 1985 to 2018
$5.3M
NIGMS NIH HHS R01 GM029123
6 · The paper itself

Abstract

We discuss theoretical and experimental approaches to three distinct developmental systems that illustrate how theory can influence experimental work and vice-versa. The chosen systems - Drosophila melanogaster, bacterial pattern formation, and pigmentation patterns - illustrate the fundamental physical processes of signaling, growth and cell division, and cell movement involved in pattern formation and development. These systems exemplify the current state of theoretical and experimental understanding of how these processes produce the observed patterns, and illustrate how theoretical and experimental approaches can interact to lead to a better understanding of development. As John Bonner said long ago'We have arrived at the stage where models are useful to suggest experiments, and the facts of the experiments in turn lead to new and improved models that suggest new experiments. By this rocking back and forth between the reality of experimental facts and the dream world of hypotheses, we can move slowly toward a satisfactory solution of the major problems of developmental biology.'

Identifiers

PMID19844610
PMCPMC2763616
OpenAlexW2116159608

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.