ArticleMolecular medicine reports
Salivary protein factors are elevated in breast cancer patients.
Article in Molecular medicine reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Salivary biomarkers in breast cancer diagnosis: A systematic review and diagnostic meta-analysis.Cancer medicine · 2022Pooled it
- Salivary biomarkers for diagnosis of systemic diseases and malignant tumors. A systematic review.Medicina oral, patologia oral y cirugia bucal · 2020Pooled it
- Defining salivary biomarkers using mass spectrometry-based proteomics: a systematic review.Omics : a journal of integrative biology · 2011Pooled it
- Salivary biomarkers for cancer diagnosis: a meta-analysis.Annals of medicinePooled it
- A Catalogue of Altered Salivary Proteins Secondary to Invasive Ductal Carcinoma: A Novel In Vivo Paradigm to Assess Breast Cancer Progression.Scientific reports · 2016Trial
- A salivary biomarker panel to detect liver cirrhosis.iScience · 2023Article
- Potential Diagnostic Value of Salivary Tumor Markers in Breast, Lung and Ovarian Cancer: A Preliminary Study.Current issues in molecular biology · 2023Article
- Article
- Identification of early biomarkers in saliva in genetically engineered mouse model C(3)1-TAg of breast cancer.Scientific reports · 2022Article
- Saliva Diagnostics.Annual review of analytical chemistry (Palo Alto, Calif.) · 2022Review
- Metabolic Features of Saliva in Breast Cancer Patients.Metabolites · 2022Article
- Salivary biomarkers in breast cancer: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Proteomics and its applications in breast cancer.American journal of cancer research · 2021Review
- Spectral fingerprinting to evaluate effects of storage conditions on biomolecular structure of filter-dried saliva samples and recovered DNA.Scientific reports · 2020Article
- Salivary exosomes: properties, medical applications, and isolation methods.Molecular biology reports · 2020Review
- Attenuated Total Reflection-Fourier Transform Infrared (ATR-FTIR) Spectroscopy Analysis of Saliva for Breast Cancer Diagnosis.Journal of oncology · 2020Article
- The Advent of Salivary Breast Cancer Biomarker Detection Using Affinity Sensors.Sensors (Basel, Switzerland) · 2019Review
- Salivary Exosomes as Nanocarriers for Cancer Biomarker Delivery.Materials (Basel, Switzerland) · 2019Review
- Salivary Glycopatterns as Potential Biomarkers for Screening of Early-Stage Breast Cancer.EBioMedicine · 2018Article
- Oral Health: The Need for Both Conventional Microbial and Molecular Characterization.High-throughput · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
While saliva is a source of easily accessible bodily fluids, there has been little effort to study its value in cancer diagnosis. We hypothesized that certain proteins would be elevated in the saliva of patients with breast cancer. Our study included 49 healthy individuals and 49 breast cancer patients. The levels of vascular endothelial growth factor (VEGF), epidermal growth factor (EGF) and carcinoembryonic antigen (CEA) in the saliva were measured with enzyme-linked immunosorbent assay (ELISA). We observed that salivary fluid protein levels were significantly elevated in cancer patients as follows: i) VEGF, 3.7±1.6 in cancer versus 2.1±1.2 ng/ml in control (p<0.0001); ii) EGF, 3.7±1.7 versus 2.1±1.3 ng/ml (p<0.0001); and iii) CEA, 83±31 versus 66.1±27.1 ng/ml (p=0.0106). The areas under the receiver operating characteristic (ROC) curve (AUC) were 80, 77 and 65%, respectively. The best prediction was from the combination of salivary VEGF and EGF with a sensitivity of 83%, specificity of 74% and AUC of 84%. We conclude that saliva is a novel avenue for tumor marker research and deserves further studies. Saliva may potentially be useful in supplementing current methods of breast cancer detection.
Indexed as
Identifiers
19844594PMC2763326W1970392917What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.