ArticleThe EMBO journal2009
Have you seen...?: Micro-managing and restraining pluripotent stem cells by MYC.
Article in The EMBO journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Regulation of Normal and Neoplastic Proliferation and Metabolism by the Extended Myc Network.Cells · 2022Review
- Article
- Linking cell signaling and the epigenetic machinery.Nature biotechnology · 2010Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The MYC proto-oncogene, which encodes a master transcriptional regulator c-Myc (herein termed Myc), has a key role in stem cell (SC) pluripotency and tumourigenesis. Its deregulated expression contributes to cancer development and enhances the efficiency of reprogramming differentiated cells back to a pluripotent state in induced pluripotent SCs (iPSCs) that resemble embryonic SCs (ESCs). In addition to Myc's ability to directly regulate mRNA transcription, it also directly regulates microRNAs (miRNAs), thus providing an additional level of complexity to gene regulation. However, it had not been well understood how the complex network of Myc target genes contributes to pluripotency in ESCs and to tumourigenesis, two phenomena that are likely inter-related. In this issue of The EMBO Journal, Lin et al (2009) document a role of Myc in the maintenance of murine ESC (mESC) pluripotency through the regulation of a set of miRNAs that suppress differentiation, in addition to those that have been previously implicated in self-renewal capacity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.