ReviewNature methods2009
Next-generation gap.
Review in Nature methods, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed.
- Fast noisy long read alignment with multi-level parallelism.BMC bioinformatics · 2025Article
- Article
- Adaptive coloration in pied flycatchers (Ecology and evolution · 2021Review
- Upscaling Statistical Patterns from Reduced Storage in Social and Life Science Big Datasets.Entropy (Basel, Switzerland) · 2020Article
- Review
- Discovering myeloid cell heterogeneity in the lung by means of next generation sequencing.Military Medical Research · 2019Review
- Review of applications of high-throughput sequencing in personalized medicine: barriers and facilitators of future progress in research and clinical application.Briefings in bioinformatics · 2019Review
- InterVar: Clinical Interpretation of Genetic Variants by the 2015 ACMG-AMP Guidelines.American journal of human genetics · 2017Article
- SePIA: RNA and small RNA sequence processing, integration, and analysis.BioData mining · 2016Article
- Characterization of Foodborne Outbreaks of Salmonella enterica Serovar Enteritidis with Whole-Genome Sequencing Single Nucleotide Polymorphism-Based Analysis for Surveillance and Outbreak Detection.Journal of clinical microbiology · 2015Article
- Toward accurate molecular identification of species in complex environmental samples: testing the performance of sequence filtering and clustering methods.Ecology and evolution · 2015Article
- An NGS Workflow Blueprint for DNA Sequencing Data and Its Application in Individualized Molecular Oncology.Cancer informatics · 2015Review
- Making sense of deep sequencing.The international journal of neuropsychopharmacology · 2014Review
- Developing eThread pipeline using SAGA-pilot abstraction for large-scale structural bioinformatics.BioMed research international · 2014Article
- SWAP-Assembler: scalable and efficient genome assembly towards thousands of cores.BMC bioinformatics · 2014Article
- The challenges of delivering bioinformatics training in the analysis of high-throughput data.Briefings in bioinformatics · 2013Article
- Article
- RNA-Seq and human complex diseases: recent accomplishments and future perspectives.European journal of human genetics : EJHG · 2013Review
- Ray Meta: scalable de novo metagenome assembly and profiling.Genome biology · 2012Article
- Cardiovascular genomics: a biomarker identification pipeline.IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a growing gap between the generation of massively parallel sequencing output and the ability to process and analyze the resulting data. New users are left to navigate a bewildering maze of base calling, alignment, assembly and analysis tools with often incomplete documentation and no idea how to compare and validate their outputs. Bridging this gap is essential, or the coveted $1,000 genome will come with a $20,000 analysis price tag.
Indexed as
Identifiers
19844227What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.