ArticleProceedings of the National Academy of Sciences of the United States of America2009
Profiling translatomes of discrete cell populations resolves altered cellular priorities during hypoxia in Arabidopsis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 341 papers, 1 of them a synthesis that pooled it.
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Who cites it
341 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic Review of Plant Ribosome Heterogeneity and Specialization.Frontiers in plant science · 2020Pooled it
- Hierarchical regulation of oxygen-sensing through coupled transducers in Arabidopsis thaliana.Nature communications · 2026Article
- Ribosome stalling position, spacing, and A-site occupancy impact translation and cotranslational mRNA decay in plants.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Distinct processes contributing to post-submergence recovery determine leaf age-specific flood resilience in Arabidopsis.Plant physiology · 2026Article
- Rorippa islandica: a genetically accessible dicot model system to study flooding tolerance.Plant physiology · 2026Article
- Chemical priming of hypoxia responses via PLANT CYSTEINE OXIDASE inhibition improves flooding tolerance.Plant physiology · 2026Article
- Genes associated with translation and oxidative phosphorylation as components of the translational response in nodulated and water-restricted soybean.BMC plant biology · 2026Article
- Spatiotemporal regulation of arbuscular mycorrhizal symbiosis at cellular resolution.The Plant cell · 2026Article
- Phosphate starvation induces root cell-type-specific transcriptional responses and alternative splicing.The New phytologist · 2026Article
- Transcriptomic Insights into Paclobutrazol-Induced Modulation of Metabolic and Signaling Pathways During Microtuberization of PotatoInternational journal of molecular sciences · 2026Article
- Are PP2Cs with intrinsically disordered regions CO2 sensors that control stomatal movements?Plant physiology · 2026Article
- The next frontier: Exploring plant hypoxia sensing and response mechanisms through synthetic biology.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Prolyl hydroxylase-dependent proteolysis enables the orthogonal hypoxia responses in plants.Nature communications · 2026Article
- Haplotype-resolved genome assembly provides insights into the evolutionary origin of waterlogging-tolerantHorticulture research · 2026Article
- Advances in seed omics.Journal of experimental botany · 2026Review
- Cross-Regulation of Metabolic and Immune Pathways in Plants Under Hypoxic Conditions.Plants (Basel, Switzerland) · 2026Review
- A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Deciphering acclimation to sublethal combined and sequential abiotic stresses in Arabidopsis thaliana.Plant physiology · 2026Article
- Functional Divergence of the Arg/N-Degron Pathway Between the CropPlant direct · 2026Article
- Discrete and cell-specific hypoxic responses in Arabidopsis roots resolved by single-nuclei transcriptomics.The New phytologist · 2026Article
281 more citing papers are in PubMed but not listed here.
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Multicellular organs are composed of distinct cell types with unique assemblages of translated mRNAs. Here, ribosome-associated mRNAs were immunopurified from specific cell populations of intact seedlings using Arabidopsis thaliana lines expressing a FLAG-epitope tagged ribosomal protein L18 (FLAG-RPL18) via developmentally regulated promoters. The profiling of mRNAs in ribosome complexes, referred to as the translatome, identified differentially expressed mRNAs in 21 cell populations defined by cell-specific expression of FLAG-RPL18. Phloem companion cells of the root and shoot had the most distinctive translatomes. When seedlings were exposed to a brief period of hypoxia, a pronounced reprioritization of mRNA enrichment in the cell-specific translatomes occurred, including a ubiquitous rise in 49 mRNAs encoding transcription factors, signaling proteins, anaerobic metabolism enzymes, and uncharacterized proteins. Translatome profiling also exposed an intricate molecular signature of transcription factor (TF) family member mRNAs that was markedly reconfigured by hypoxia at global and cell-specific levels. In addition to the demonstration of the complexity and plasticity of cell-specific populations of ribosome-associated mRNAs, this study provides an in silico dataset for recognition of differentially expressed genes at the cell-, region-, and organ-specific levels.
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