ArticleNucleic acids research2009
Expression profiling of Drosophila mitochondrial genes via deep mRNA sequencing.
Article in Nucleic acids research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 62 citations in OpenAlex.
- Review
- The PPR domain of mitochondrial RNA polymerase is an exoribonuclease required for mtDNA replication in Drosophila melanogaster.Nature cell biology · 2022Article
- Loss of Individual Mitochondrial Ribonuclease P Complex Proteins Differentially Affects Mitochondrial tRNA Processing In Vivo.International journal of molecular sciences · 2021Article
- Genomes, expression profiles, and diversity of mitochondria of the White-footed Deermouse Peromyscus leucopus, reservoir of Lyme disease and other zoonoses.Scientific reports · 2019Article
- Improved annotation of protein-coding genes boundaries in metazoan mitochondrial genomes.Nucleic acids research · 2019Article
- The Evolution of Dark Matter in the Mitogenome of Seed Beetles.Genome biology and evolution · 2017Article
- Variation and evolution of polyadenylation profiles in sauropsid mitochondrial mRNAs as deduced from the high-throughput RNA sequencing.BMC genomics · 2017Article
- Mitochondrial Genomes Provide Insights into the Phylogeny of Lauxanioidea (Diptera: Cyclorrhapha).International journal of molecular sciences · 2017Article
- Complete mitogenome of Hainan medakaMitochondrial DNA. Part B, Resources · 2017Article
- Initiation of mtDNA transcription is followed by pausing, and diverges across human cell types and during evolution.Genome research · 2017Article
- TraditionalGenomics data · 2017Article
- Mitochondrial-Nuclear Interactions Mediate Sex-Specific Transcriptional Profiles in Drosophila.Genetics · 2016Article
- Loss of the mitochondrial protein-only ribonuclease P complex causes aberrant tRNA processing and lethality in Drosophila.Nucleic acids research · 2016Article
- Complete mitochondrial genome of the spotted-wing drosophila,Mitochondrial DNA. Part B, Resources · 2016Article
- Complete Mitochondrial Genome of Helicoverpa zea (Lepidoptera: Noctuidae) and Expression Profiles of Mitochondrial-Encoded Genes in Early and Late Embryos.Journal of insect science (Online) · 2016Article
- Knockout of Drosophila RNase ZL impairs mitochondrial transcript processing, respiration and cell cycle progression.Nucleic acids research · 2015Article
- Mapping 3' transcript ends in the bank vole (Clethrionomys glareolus) mitochondrial genome with RNA-Seq.BMC genomics · 2015Article
- SUV3 helicase is required for correct processing of mitochondrial transcripts.Nucleic acids research · 2015Article
- Simultaneous DNA and RNA Mapping of Somatic Mitochondrial Mutations across Diverse Human Cancers.PLoS genetics · 2015Article
- Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Mitochondria play an essential role in several cellular processes. Nevertheless, very little is known about patterns of gene expression of genes encoded by the mitochondrial DNA (mtDNA). In this study, we used next-generation sequencing (NGS) for transcription profiling of genes encoded in the mitochondrial genome of Drosophila melanogaster and D. pseudoobscura. The analysis of males and females in both species indicated that the expression pattern was conserved between the two species, but differed significantly between both sexes. Interestingly, mRNA levels were not only different among genes encoded by separate transcription units, but also showed significant differences among genes located in the same transcription unit. Hence, mRNA abundance of genes encoded by mtDNA seems to be heavily modulated by post-transcriptional regulation. Finally, we also identified several transcripts with a noncanonical structure, suggesting that processing of mitochondrial transcripts may be more complex than previously assumed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.