ArticleJournal of cell science2009
Xenopus delta-catenin is essential in early embryogenesis and is functionally linked to cadherins and small GTPases.
Article in Journal of cell science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Role of a Pdlim5:PalmD complex in directing dendrite morphology.Frontiers in cellular neuroscience · 2024Article
- p120-catenin subfamily members have distinct as well as shared effects on dendrite morphology during neuron developmentFrontiers in cellular neuroscience · 2023Article
- Delta-Catenin as a Modulator of Rho GTPases in Neurons.Frontiers in cellular neuroscience · 2022Review
- A catenin of the plakophilin-subfamily, Pkp3, responds to canonical-Wnt pathway components and signals.Biochemical and biophysical research communications · 2021Article
- Use of a Network-Based Method to Identify Latent Genes Associated with Hearing Loss in Children.Frontiers in cell and developmental biology · 2021Article
- Disruption ofHGG advances · 2020Article
- Novel truncating mutations in CTNND1 cause a dominant craniofacial and cardiac syndrome.Human molecular genetics · 2020Article
- A role for proteolytic regulation of δ-catenin in remodeling a subpopulation of dendritic spines in the rodent brain.The Journal of biological chemistry · 2018Article
- Functional roles of p120ctn family of proteins in central neurons.Seminars in cell & developmental biology · 2017Review
- Article
- Nuclear signaling from cadherin adhesion complexes.Current topics in developmental biology · 2015Review
- A conserved Oct4/POUV-dependent network links adhesion and migration to progenitor maintenance.Current biology : CB · 2013Article
- Down's-syndrome-related kinase Dyrk1A modulates the p120-catenin-Kaiso trajectory of the Wnt signaling pathway.Journal of cell science · 2012Article
- Plakophilin-3 is required for late embryonic amphibian development, exhibiting roles in ectodermal and neural tissues.PloS one · 2012Article
- Kazrin, and its binding partners ARVCF- and delta-catenin, are required for Xenopus laevis craniofacial development.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
- Pronephric tubulogenesis requires Daam1-mediated planar cell polarity signaling.Journal of the American Society of Nephrology : JASN · 2011Article
- Caspase-3 cleavage links delta-catenin to the novel nuclear protein ZIFCAT.The Journal of biological chemistry · 2011Article
- The molecular evolution of the p120-catenin subfamily and its functional associations.PloS one · 2010Article
- Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members.Journal of cell science · 2010Article
- Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity.Journal of cell science · 2010Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Catenins of the p120 subclass display an array of intracellular localizations and functions. Although the genetic knockout of mouse delta-catenin results in mild cognitive dysfunction, we found severe effects of its depletion in Xenopus. delta-catenin in Xenopus is transcribed as a full-length mRNA, or as three (or more) alternatively spliced isoforms designated A, B and C. Further structural and functional complexity is suggested by three predicted and alternative translation initiation sites. Transcript analysis suggests that each splice isoform is expressed during embryogenesis, with the B and C transcript levels varying according to developmental stage. Unlike the primarily neural expression of delta-catenin reported in mammals, delta-catenin is detectable in most adult Xenopus tissues, although it is enriched in neural structures. delta-catenin associates with classical cadherins, with crude embryo fractionations further revealing non-plasma-membrane pools that might be involved in cytoplasmic and/or nuclear functions. Depletion of delta-catenin caused gastrulation defects, phenotypes that were further enhanced by co-depletion of the related p120-catenin. Depletion was significantly rescued by titrated p120-catenin expression, suggesting that these catenins have shared roles. Biochemical assays indicated that delta-catenin depletion results in reduced cadherin levels and cell adhesion, as well as perturbation of RhoA and Rac1. Titrated doses of C-cadherin, dominant-negative RhoA or constitutively active Rac1 significantly rescued delta-catenin depletion. Collectively, our experiments indicate that delta-catenin has an essential role in amphibian development, and has functional links to cadherins and Rho-family GTPases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.