ArticleThe Journal of biological chemistry2009
Vesicular inhibitory amino acid transporter is a Cl-/gamma-aminobutyrate Co-transporter.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 52 citations in OpenAlex.
- The SLC-ome of membrane transport: from molecular discovery to physiology and clinical applications.Physiological reviews · 2026Review
- Dopamine-Glutamate and Dopamine-GABA Co-release.Advances in neurobiology · 2025Review
- Fundamental Neurochemistry Review: The role of enteroendocrine cells in visceral pain.Journal of neurochemistry · 2023Review
- Transcriptomic and Behavioral Studies of Small Yellow Croaker (Animals : an open access journal from MDPI · 2022Article
- The druggable schizophrenia genome: from repurposing opportunities to unexplored drug targets.NPJ genomic medicine · 2022Review
- Genomic analysis of Asian honeybee populations in China reveals evolutionary relationships and adaptation to abiotic stress.Ecology and evolution · 2020Article
- Expression of plasma membrane calcium ATPases confers CaScientific reports · 2019Article
- Dlx1 and Dlx2 Promote Interneuron GABA Synthesis, Synaptogenesis, and Dendritogenesis.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- VGLUT1 functions as a glutamate/proton exchanger with chloride channel activity in hippocampal glutamatergic synapses.Nature communications · 2017Article
- Cl-out is a novel cooperative optogenetic tool for extruding chloride from neurons.Nature communications · 2016Article
- Unique pH dynamics in GABAergic synaptic vesicles illuminates the mechanism and kinetics of GABA loading.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Co-existence of Functionally Different Vesicular Neurotransmitter Transporters.Frontiers in synaptic neuroscience · 2016Review
- Presynaptic Molecular Determinants of Quantal Size.Frontiers in synaptic neuroscience · 2016Review
- Impairment of vesicular ATP release affects glucose metabolism and increases insulin sensitivity.Scientific reports · 2014Article
- Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives.Frontiers in cellular neuroscience · 2014Review
- Molecular dialogue between the human gut microbiota and the host: a Lactobacillus and Bifidobacterium perspective.Cellular and molecular life sciences : CMLS · 2014Review
- The Amino Acid Transporters of the Glutamate/GABA-Glutamine Cycle and Their Impact on Insulin and Glucagon Secretion.Frontiers in endocrinology · 2013Review
- The Concise Guide to PHARMACOLOGY 2013/14: transporters.British journal of pharmacology · 2013Article
- Are vesicular neurotransmitter transporters potential treatment targets for temporal lobe epilepsy?Frontiers in cellular neuroscience · 2013Review
- Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vesicular inhibitory amino acid transporter (VIAAT) is a synaptic vesicle protein responsible for the vesicular storage of gamma-aminobutyrate (GABA) and glycine which plays an essential role in GABAergic and glycinergic neurotransmission. The transport mechanism of VIAAT remains largely unknown. Here, we show that proteoliposomes containing purified VIAAT actively took up GABA upon formation of membrane potential (Deltapsi) (positive inside) but not DeltapH. VIAAT-mediated GABA uptake had an absolute requirement for Cl(-) and actually accompanied Cl(-) movement. Kinetic analysis indicated that one GABA molecule and two Cl(-) equivalents were transported during one transport cycle. VIAAT in which Glu(213) was specifically mutated to alanine completely lost the ability to take up both GABA and Cl(-). Essentially the same results were obtained with glycine, another substrate of VIAAT. These results demonstrated that VIAAT is a vesicular Cl(-) transporter that co-transports Cl(-) with GABA or glycine in a Deltapsi dependent manner. It is concluded that Cl(-) plays an essential role in vesicular storage of GABA and glycine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.