ArticleBiophysical journal2009
Cell-wall interactions and the selective bacteriostatic activity of a miniature oligo-acyl-lysyl.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
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- A glycine zipper motif is required for the translocation of a T6SS toxic effector into target cells.EMBO reports · 2023Article
- Synergy by Perturbing the Gram-Negative Outer Membrane: Opening the Door for Gram-Positive Specific Antibiotics.ACS infectious diseases · 2022Review
- Advances in Development of Antimicrobial Peptidomimetics as Potential Drugs.Molecules (Basel, Switzerland) · 2017Review
- A broad-spectrum bactericidal lipopeptide with anti-biofilm properties.Scientific reports · 2017Article
- The highly synergistic, broad spectrum, antibacterial activity of organic acids and transition metals.Scientific reports · 2017Article
- Sensitization of Gram-negative bacteria to rifampin and OAK combinations.Scientific reports · 2015Article
- Cationic methacrylate polymers as topical antimicrobial agents against Staphylococcus aureus nasal colonization.Biomacromolecules · 2014Article
- Nontraditional therapies to treat Helicobacter pylori infection.Journal of microbiology (Seoul, Korea) · 2014Review
- PHACOS, a functionalized bacterial polyester with bactericidal activity against methicillin-resistant Staphylococcus aureus.Biomaterials · 2014Article
- Molecular design, structures, and activity of antimicrobial peptide-mimetic polymers.Macromolecular bioscience · 2013Article
- Poly(ethylene imine)s as antimicrobial agents with selective activity.Macromolecular bioscience · 2012Article
- The oligo-acyl lysyl antimicrobial peptide C₁₂K-2β₁₂ exhibits a dual mechanism of action and demonstrates strong in vivo efficacy against Helicobacter pylori.Antimicrobial agents and chemotherapy · 2012Article
- Antiplasmodial properties of acyl-lysyl oligomers in culture and animal models of malaria.Antimicrobial agents and chemotherapy · 2011Article
- Lipid complexes with cationic peptides and OAKs; their role in antimicrobial action and in the delivery of antimicrobial agents.Cellular and molecular life sciences : CMLS · 2011Review
- Mechanisms mediating bactericidal properties and conditions that enhance the potency of a broad-spectrum oligo-acyl-lysyl.Antimicrobial agents and chemotherapy · 2011Article
- A miniature mimic of host defense peptides with systemic antibacterial efficacy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Probing the "charge cluster mechanism" in amphipathic helical cationic antimicrobial peptides.Biochemistry · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The oligo-acyl-lysyl, C(12(omega 7))K-beta(12), is comprised of only three Lys residues. Despite its small size, it exhibits potent bacteriostatic activity against Gram-positive bacteria, but it is approximately 10-fold less potent against Gram-negative bacteria. We followed the interactions of C(12(omega 7))K-beta(12) from its initial contact with the bacterial surface across the cell wall down to the cytoplasmic membrane. Binding to anionic lipids, as well as to negatively charged LPS and LTA, occurs with very high affinity. The C(12(omega 7))K-beta(12) does not cross the outer membrane of Gram-negative bacteria; rather, it achieves its action by depositing on the LPS layer, promoting surface adhesion and blocking passage of solutes. In Gram-positive bacteria, the thick peptidoglycan layer containing LTA allows passage of C(12(omega 7))K-beta(12) and promotes its accumulation in the small periplasm. From that location it is then driven to the membrane by strong electrostatic interactions. Despite its high potency against Gram-positive bacteria, this agent is not capable of efficiently breaking down the permeability barrier of the cytoplasmic membrane or of reaching an intracellular target, as suggested by the fact that it does not interact with DNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.