ArticleBiophysical journal2009
Reinterpreting the anomalous mole fraction effect: the ryanodine receptor case study.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- A Model Framework for Ion Channels with Selectivity Filters Based on Non-Equilibrium Thermodynamics.Entropy (Basel, Switzerland) · 2025Article
- Modeling the Device Behavior of Biological and Synthetic Nanopores with Reduced Models.Entropy (Basel, Switzerland) · 2020Article
- The mixture effect on ionic selectivity and permeability of nanotubes.Nanoscale advances · 2020Article
- Comparison of permeation mechanisms in sodium-selective ion channels.Neuroscience letters · 2019Review
- Selective ion permeation involves complexation with carboxylates and lysine in a model human sodium channel.PLoS computational biology · 2018Article
- In silico assessment of the conduction mechanism of the Ryanodine Receptor 1 reveals previously unknown exit pathways.Scientific reports · 2018Article
- Dampened activity of ryanodine receptor channels in mutant skeletal muscle lacking TRIC-A.The Journal of physiology · 2017Article
- Article
- Selecting ions by size in a calcium channel: the ryanodine receptor case study.Biophysical journal · 2014Article
- Sarcoplasmic reticulum K(+) (TRIC) channel does not carry essential countercurrent during Ca(2+) release.Biophysical journal · 2013Article
- Interacting ions in biophysics: real is not ideal.Biophysical journal · 2013Review
- Pernicious attrition and inter-RyR2 CICR current control in cardiac muscle.Journal of molecular and cellular cardiology · 2013Review
- TRIC channels supporting efficient Ca(2+) release from intracellular stores.Pflugers Archiv : European journal of physiology · 2013Review
- Ion correlations in nanofluidic channels: effects of ion size, valence, and concentration on voltage- and pressure-driven currents.Langmuir : the ACS journal of surfaces and colloids · 2013Article
- Is ryanodine receptor a calcium or magnesium channel? Roles of K+ and Mg2+ during Ca2+ release.Cell calcium · 2012Article
- Ionizable side chains at catalytic active sites of enzymes.European biophysics journal : EBJ · 2012Article
- Current and selectivity in a model sodium channel under physiological conditions: Dynamic Monte Carlo simulations.Biochimica et biophysica acta · 2012Article
- Selectivity sequences in a model calcium channel: role of electrostatic field strength.European biophysics journal : EBJ · 2011Article
- Single ryanodine receptor channel basis of caffeine's action on Ca2+ sparks.Biophysical journal · 2011Article
- Analyzing the components of the free-energy landscape in a calcium selective ion channel by Widom's particle insertion method.The Journal of chemical physics · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The origin of the anomalous mole fraction effect (AMFE) in calcium channels is explored with a model of the ryanodine receptor. This model predicted and experiments verified new AMFEs in the cardiac isoform. In mole fraction experiments, conductance is measured in mixtures of ion species X and Y as their relative amounts (mole fractions) vary. This curve can have a minimum (an AMFE). The traditional interpretation of the AMFE is that multiple interacting ions move through the pore in a single file. Mole fraction curves without minima (no AMFEs) are generally interpreted as X displacing Y from the pore in a proportion larger than its bath mole fraction (preferential selectivity). We find that the AMFE is also caused by preferential selectivity of X over Y, if X and Y have similar conductances. This is a prediction applicable to any channel and provides a fundamentally different explanation of the AMFE that does not require single filing or multiple occupancy: preferential selectivity causes the resistances to current flow in the baths, channel vestibules, and selectivity filter to change differently with mole fraction, and produce the AMFE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.