Evidence map›Paper›PMID 19843412›Full record

ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2009

Reduced antibiotic prescribing for acute respiratory infections in adults and children.

Sharon B Meropol, Zhen Chen, Joshua P Metlay

Open access · bronzeAbstract read
In one paragraph

Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 42 citations in OpenAlex.

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  8. Infectious disease burden and antibiotic prescribing in primary care in Israel.Annals of clinical microbiology and antimicrobials · 2018
    Article
  9. Article
  10. The rate of antibiotic utilization in Iranian under 5-year-old children with acute respiratory tract illness: A nationwide community-based study.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015
    Article
  11. Childhood urinary tract infection in primary care: a prospective observational study of prevalence, diagnosis, treatment, and recovery.The British journal of general practice : the journal of the Royal College of General Practitioners · 2015
    Observational
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  18. Reducing uncertainty in managing respiratory tract infections in primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2010
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  19. The future role of pharmacists in primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2009
    Article
  20. Respiratory infections.The British journal of general practice : the journal of the Royal College of General Practitioners · 2009
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Sharon B MeropolCenter for Clinical Epidemiology and Biostatistics, Penn Center for Education and Research on Therapeutics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. meropols@mail.med.upenn.edu
Zhen Chen
Joshua P Metlay
California University of Pennsylvania · USUniversity of Pennsylvania · US

Funding

Center For Education and Research in TherapeuticsU18HS016946 · AHRQ · UNIVERSITY OF PENNSYLVANIA · PI STROM, BRIAN LESLIE · 2007 to 2010
$4.0M
Antibiotic Use and Adverse EventsF32AI073015 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI MEROPOL, SHARON B · 2007 to 2009
$220k
AHRQ HHS U18-HS-016946NIAID NIH HHS F32 AI073015NIAID NIH HHS F32-AI-073015-01A1
6 · The paper itself

Abstract

backgroundRecent public health efforts, including in the UK and US, have targeted decreasing unnecessary antibiotic use. In the US, prescribing for acute non-specific respiratory infections (ARIs) has decreased, but broad-spectrum antibacterial prescribing has soared.

aimTo assess recent trends in antibacterial prescribing for ARIs in the UK. DESIGN OF STUDY: Retrospective cohort.

settingThe Health Improvement Network database.

methodOutpatient ARI visits from 1 January 1990 to 31 December 2004 were selected. Outcomes were antibacterial and broad-spectrum antibacterial prescriptions per thousand person-years, and the probability of receiving an antibacterial and broad-spectrum prescription conditional on an ARI visit.

resultsFrom 1990 to 2004, antibacterial prescribing rates for ARIs decreased from 55.0 to 30.3 prescriptions/1000 person-years for adults and from 124.8 to 46.3 prescriptions/1000 person-years for children (P=0.001). The probability of receiving an antibacterial prescription after an ARI visit decreased from 70.8% to 59.5% for adults and from 46.1% to 30.8% for children (P=0.003 and 0.007, respectively). Antibacterial prescribing declined faster for younger than for older adults. Broad-spectrum antibacterial prescribing rates decreased from 3.8 to 2.9 prescriptions/1000 person-years for adults and from 5.2 to 2.2 prescriptions/1000 person years for children (P=0.005 and 0.003, respectively). The probability of broad-spectrum prescribing did not demonstrate a significant linear trend for adults (P=0.16), and decreased for children (P=0.01).

conclusionUK antibacterial prescribing for ARIs has declined, similar to US trends, but there was no concomitant increase in low broad-spectrum prescribing. The success of UK strategies for limiting antimicrobial use has implications for programmes in other countries.

Indexed as

Prescription DrugsAcute DiseaseAdolescentAdultAgedAnti-Bacterial AgentsChildChild, PreschoolDatabases as TopicDrug PrescriptionsEpidemiologic MethodsHumansInfantMiddle AgedPractice Patterns, Physicians'Respiratory Tract InfectionsAnti-Bacterial AgentsPrescription Drugs

Identifiers

PMID19843412
PMCPMC2751936
OpenAlexW2107466754

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.