ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2009
Viral infection induces de novo lesions of coronary allograft vasculopathy through a natural killer cell-dependent pathway.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Cytomegalovirus infection and cardiovascular outcomes in abdominal organ transplant recipients: A systematic review and meta-analysis.Transplantation reviews (Orlando, Fla.) · 2024Pooled it
- Kidney transplant arteriopathy revisited.Journal of nephrology · 2025Article
- Decoding immune cell interactions during cardiac allograft vasculopathy: insights derived from bioinformatic strategies.Frontiers in cardiovascular medicine · 2025Review
- NK Cells: Not Just Followers But Also Initiators of Chronic Vascular Rejection.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
- Cardiac allograft vasculopathy: current review and future research directions.Cardiovascular research · 2021Review
- Macrophage depletion of CMV latently infected donor hearts ameliorates recipient accelerated chronic rejection.Transplant infectious disease : an official journal of the Transplantation Society · 2021Article
- Regadenoson-induced hyperemia for absolute myocardial blood flow quantitation byJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- The Microbiome, Systemic Immune Function, and Allotransplantation.Clinical microbiology reviews · 2016Review
- De novo development of antibodies to kidney-associated self-antigens angiotensin II receptor type I, collagen IV, and fibronectin occurs at early time points after kidney transplantation in children.Pediatric transplantation · 2015Article
- Dendritic cells and innate immunity in kidney transplantation.Kidney international · 2015Review
- Depletion of T regulatory cells promotes natural killer cell-mediated cardiac allograft vasculopathy.Transplantation · 2014Article
- Tim-1-Fc suppresses chronic cardiac allograft rejection and vasculopathy by reducing IL-17 production.International journal of clinical and experimental pathology · 2014Article
- Evolving concepts and treatment strategies for cardiac allograft vasculopathy.Current treatment options in cardiovascular medicine · 2014Article
- Mechanisms of chronic cardiac allograft rejection.Texas Heart Institute journal · 2013Review
- Unlinked memory helper responses promote long-lasting humoral alloimmunity.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Innate immunity alone is not sufficient for chronic rejection but predisposes healed allografts to T cell-mediated pathology.Transplant immunology · 2012Article
- A novel pathway of chronic allograft rejection mediated by NK cells and alloantibody.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2012Article
- Early cardiac allograft vasculopathy: are the viruses to blame?Case reports in medicine · 2012Article
- Detection of parvovirus B19 and human herpesvirus 6 in pediatric dilated cardiomyopathy: Impact after heart transplantation.Annals of pediatric cardiologyArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Viral infections including those due to cytomegalovirus have been associated with accelerated cardiac allograft vasculopathy (CAV) in clinical trials and some animal models. Evidence demonstrating a direct causal relationship between such infections and de novo formation of coronary vascular lesions is lacking. Heterotopic murine cardiac transplants were performed in a parental to F1 combination in animals lacking both T- and B-lymphocytes (RAG(-/-)). Coronary vasculopathy developed almost exclusively in the presence of recipient infection with lymphocytic choriomeningitis virus but not in uninfected controls. This process was also dependent upon the presence of natural killer (NK) cells as depletion of NK cells abrogated the process. These data show that a viral infection in its native host, and not previously implicated in the production of CAV, can contribute to the development of advanced coronary vascular lesions in cardiac allotransplants in mice. These data also suggest that virus-induced CAV can develop via an NK-cell-dependent pathway in the absence of T- and B-lymphocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.