ReviewWorld journal of gastroenterology2009
Biochemical mechanisms in drug-induced liver injury: certainties and doubts.
Review in World journal of gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 132 citations in OpenAlex.
- Precision treatment and frontier advances of glycyrrhizin preparations in drug-induced liver injury (DILI).Frontiers in pharmacology · 2026Review
- Specific effects on liver relevant for performing a dietary cumulative risk assessment of pesticide residues.EFSA journal. European Food Safety Authority · 2025Article
- Article
- Diclofenac sensitizes multi-drug resistant Acinetobacter baumannii to colistin.PLoS pathogens · 2024Article
- Exploring Acute Liver Damage: Slimming Health Foods and CYP3A4 Induction.Yonago acta medica · 2024Article
- Review
- A comparative study on the implementation of deep learning algorithms for detection of hepatic necrosis in toxicity studies.Toxicological research · 2023Article
- Latest impact of engineered human liver platforms on drug development.APL bioengineering · 2021Review
- In Vitro Liver Toxicity Testing of Chemicals: A Pragmatic Approach.International journal of molecular sciences · 2021Review
- High-Content Screening for the Detection of Drug-Induced Oxidative Stress in Liver Cells.Antioxidants (Basel, Switzerland) · 2021Review
- Exploring Liver Mitochondrial Function byMethods in molecular biology (Clifton, N.J.) · 2021Article
- A Critical Perspective on 3D Liver Models for Drug Metabolism and Toxicology Studies.Frontiers in cell and developmental biology · 2021Review
- Bile Acids and GPBAR-1: Dynamic Interaction Involving Genes, Environment and Gut Microbiome.Nutrients · 2020Review
- Challenges in early identification of causes and treatment of cholestasis in patients with hyperthyroidism: a case report and literature review.The Journal of international medical research · 2020Review
- Next generationHepatobiliary surgery and nutrition · 2020Article
- Effects of Different Processed Products ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- High-content analysis ofJournal of veterinary science · 2019Article
- Influence Factors on the Hepatotoxicity ofEvidence-based complementary and alternative medicine : eCAM · 2019Review
- Therapeutic Protection from Hepatic Injury and Chemical Constituents ofTurkish journal of pharmaceutical sciences · 2018Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug-induced liver injury is a significant and still unresolved clinical problem. Limitations to knowledge about the mechanisms of toxicity render incomplete the detection of hepatotoxic potential during preclinical development. Several xenobiotics are lipophilic substances and their transformation into hydrophilic compounds by the cytochrome P-450 system results in production of toxic metabolites. Aging, preexisting liver disease, enzyme induction or inhibition, genetic variances, local O(2) supply and, above all, the intrinsic molecular properties of the drug may affect this process. Necrotic death follows antioxidant consumption and oxidation of intracellular proteins, which determine increased permeability of mitochondrial membranes, loss of potential, decreased ATP synthesis, inhibition of Ca(2+)-dependent ATPase, reduced capability to sequester Ca(2+) within mitochondria, and membrane bleb formation. Conversely, activation of nucleases and energetic participation of mitochondria are the main intracellular mechanisms that lead to apoptosis. Non-parenchymal hepatic cells are inducers of hepatocellular injury and targets for damage. Activation of the immune system promotes idiosyncratic reactions that result in hepatic necrosis or cholestasis, in which different HLA genotypes might play a major role. This review focuses on current knowledge of the mechanisms of drug-induced liver injury and recent advances on newly discovered mechanisms of liver damage. Future perspectives including new frontiers for research are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.