ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
Osteoblast maturation occurs in overlapping proximal-distal compartments during fin regeneration in zebrafish.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Common and specific gene regulatory programs in zebrafish caudal fin regeneration at single-cell resolution.Genome research · 2025Article
- Compartmentalization and synergy of osteoblasts drive bone formation in the regenerating fin.iScience · 2024Article
- Insulin-like growth factor receptor / mTOR signaling elevates global translation to accelerate zebrafish fin regenerative outgrowth.Developmental biology · 2023Article
- Article
- Zebrafish caudal fin as a model to investigate the role of probiotics in bone regeneration.Scientific reports · 2022Article
- Single-cell resolution of MET- and EMT-like programs in osteoblasts during zebrafish fin regeneration.iScience · 2022Article
- Osteoblasts pattern endothelium and somatosensory axons during zebrafish caudal fin organogenesis.Development (Cambridge, England) · 2022Article
- Connexin Communication Compartments and Wound Repair in Epithelial Tissue.International journal of molecular sciences · 2018Review
- Widening control of fin inter-rays in zebrafish and inferences about actinopterygian fins.Journal of anatomy · 2018Article
- Cx43 suppresses evx1 expression to regulate joint initiation in the regenerating fin.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Article
- Quantitative assessment of the regenerative and mineralogenic performances of the zebrafish caudal fin.Scientific reports · 2016Article
- Osteogenic programs during zebrafish fin regeneration.BoneKEy reports · 2015Review
- Mechanistic target of rapamycin complex 1 signaling regulates cell proliferation, cell survival, and differentiation in regenerating zebrafish fins.BMC developmental biology · 2014Article
- Specific NuRD components are required for fin regeneration in zebrafish.BMC biology · 2014Article
- Determining how defects in connexin43 cause skeletal disease.Genesis (New York, N.Y. : 2000) · 2013Review
- Article
- Semaphorin3d mediates Cx43-dependent phenotypes during fin regeneration.Developmental biology · 2012Article
- Limited dedifferentiation provides replacement tissue during zebrafish fin regeneration.Developmental biology · 2012Article
- Attenuated BMP1 function compromises osteogenesis, leading to bone fragility in humans and zebrafish.American journal of human genetics · 2012Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
During fin regeneration, osteoblasts must continually differentiate for outgrowth of the bony fin rays. Bone maturity increases in a distal-proximal manner, and osteoblast maturation can be detected similarly when following gene expression. We find that early markers for osteoblast differentiation are expressed in a discrete domain at the distal end of the fin, just proximal to the adjacent germinal compartment of dividing cells. Matrix genes, required at later stages developmentally, are expressed in a population of cells proximally to the early genes. A marker for mature osteoblasts is expressed in cells further proximal. These domains of gene expression are partially overlapping, perhaps revealing additional levels of osteoblast maturity. We suggest a model for growth where new cells are continually added to the distal-most osteoblast compartment, while osteoblasts in more proximal locations differentiate, thus translating developmental time to location on the proximal-distal axis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.