ArticleProteins2010
Nitric oxide conduction by the brain aquaporin AQP4.
Article in Proteins, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 105 citations in OpenAlex.
- Characterization and Computational Engineering of Structural Elements Controlling Gas Permeability in PIP2;1 Aquaporins.Journal of computational chemistry · 2026Article
- Urea Transport Mediated by Membrane Proteins of Non-urea-Transporters.Sub-cellular biochemistry · 2025Review
- Peroxiporins in Triple-Negative Breast Cancer: Biomarker Potential and Therapeutic Perspectives.International journal of molecular sciences · 2024Review
- Aquaporin water channels: roles beyond renal water handling.Nature reviews. Nephrology · 2023Review
- Pathophysiology and Neuroimmune Interactions Underlying Parkinson's Disease and Traumatic Brain Injury.International journal of molecular sciences · 2023Review
- Transport Characteristics of Aquaporins.Advances in experimental medicine and biology · 2023Article
- Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease.International journal of molecular sciences · 2022Review
- Aquaporins: New players in breast cancer progression and treatment response.Frontiers in oncology · 2022Review
- Mechanistic Understanding from Molecular Dynamics in Pharmaceutical Research 2: Lipid Membrane in Drug Design.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Atomistic simulations modify interpretation of spin-label oximetry data. Part 1: intensified water-lipid interfacial resistances.Applied magnetic resonance · 2021Article
- Genome-wide identification and expression analysis of aquaporin family in Canavalia rosea and their roles in the adaptation to saline-alkaline soils and drought stress.BMC plant biology · 2021Article
- Disease-Induced Modulation of Drug Transporters at the Blood-Brain Barrier Level.International journal of molecular sciences · 2021Review
- Article
- A Perspective: Active Role of Lipids in Neurotransmitter Dynamics.Molecular neurobiology · 2020Review
- Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance.Chemical reviews · 2019Article
- Transport of Reactive Oxygen and Nitrogen Species across Aquaporin: A Molecular Level Picture.Oxidative medicine and cellular longevity · 2019Article
- Bacterial denitrifying nitric oxide reductases and aerobic respiratory terminal oxidases use similar delivery pathways for their molecular substrates.Biochimica et biophysica acta. Bioenergetics · 2018Article
- Cytochrome aaBiochemistry · 2018Article
- How Supraphysiological Oxygen Levels in Standard Cell Culture Affect Oxygen-Consuming Reactions.Oxidative medicine and cellular longevity · 2018Review
- Plant and animal aquaporins crosstalk: what can be revealed from distinct perspectives.Biophysical reviews · 2017Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Involvement of aquaporins in gas conduction across the membrane and the physiological significance of this process have attracted marked attention from both experimental and theoretical studies. Previous work demonstrated that AQP1 is permeable to both CO(2) and O(2). Here we employ various simulation techniques to examine the permeability of the brain aquaporin AQP4 to NO and O(2) and to describe energetics and pathways associated with these phenomena. The energy barrier to NO and O(2) permeation through AQP4 central pore is found to be only approximately 3 kcal mol(-1). The results suggest that the central pore of AQP4, similar to that of AQP1, can indeed conduct gas molecules. Interestingly, despite a longer and narrower central pore, AQP4 appears to provide an energetically more favorable permeation pathway for gas molecules than AQP1, mainly due to the different orientation of its charged residues near the pore entrance. Although the low barrier against gas permeation through AQP4 indicates that it can participate in gas conduction across the cellular membrane, physiological relevance of the phenomenon remains to be established experimentally, particularly since pure lipid bilayers appear to present a more favorable pathway for gas conduction across the membrane. With an energy well of -1.8 kcal mol(-1), the central pore of AQP4 may also act as a reservoir for NO molecules to accumulate in the membrane.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.