ArticleDevelopmental psychobiology2010
Dopamine receptors modulate ethanol's locomotor-activating effects in preweanling rats.
Article in Developmental psychobiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 26 citations in OpenAlex.
- C57BL/6J offspring mice reared by a single-mother exhibit, compared to mice reared in a biparental parenting structure, distinct neural activation patterns and heightened ethanol-induced anxiolysis.Psychopharmacology · 2025Article
- Functional characterization of the cannabinoid receptors 1 and 2 in zebrafish larvae using behavioral analysis.Psychopharmacology · 2019Article
- Behavioral Sensitization to the Disinhibition Effect of Ethanol Requires the Dopamine/Ecdysone Receptor inFrontiers in systems neuroscience · 2017Article
- Differential effects of acute administration of SCH-23390, a D₁ receptor antagonist, and of ethanol on swimming activity, anxiety-related responses, and neurochemistry of zebrafish.Psychopharmacology · 2015Article
- Participation of the nociceptin/orphanin FQ receptor in ethanol-mediated locomotor activation and ethanol intake in preweanling rats.Behavioural brain research · 2013Article
- Greater ethanol-induced locomotor activation in DBA/2J versus C57BL/6J mice is not predicted by presynaptic striatal dopamine dynamics.PloS one · 2013Article
- Acetaldehyde reinforcement and motor reactivity in newborns with or without a prenatal history of alcohol exposure.Frontiers in behavioral neuroscience · 2013Article
- Acetaldehyde involvement in ethanol's postabsortive effects during early ontogeny.Frontiers in behavioral neuroscience · 2013Article
- Chronic tolerance to the locomotor stimulating effect of ethanol in preweanling rats as a function of social stress.Alcohol (Fayetteville, N.Y.) · 2012Article
- Mianserin, but not ondansetron, reduces the locomotor stimulating effect of ethanol in preweanling rats.Pharmacology, biochemistry, and behavior · 2011Article
- Naloxone blocks ethanol-mediated appetitive conditioning and locomotor activation in adolescent rats.Behavioural brain research · 2011Article
- A comparison between taste avoidance and conditioned disgust reactions induced by ethanol and lithium chloride in preweanling rats.Developmental psychobiology · 2010Article
- Social isolation and stress related hormones modulate the stimulating effect of ethanol in preweanling rats.Behavioural brain research · 2010Article
- High ethanol dose during early adolescence induces locomotor activation and increases subsequent ethanol intake during late adolescence.Developmental psychobiology · 2010Article
- Ethanol-mediated aversive learning as a function of locomotor activity in a novel environment in infant Sprague-Dawley rats.Pharmacology, biochemistry, and behavior · 2009Article
- Novelty modulates the stimulating motor effects of ethanol in preweanling rats.Pharmacology, biochemistry, and behavior · 2009Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Near the end of the second postnatal week motor activity is increased soon after ethanol administration (2.5 g/kg) while sedation-like effects prevail when blood ethanol levels reach peak values. This time course coincides with biphasic reinforcement (appetitive and aversive) effects of ethanol determined at the same age. The present experiments tested the hypothesis that ethanol-induced activity during early development in the rat depends on the dopamine system, which is functional in modulating motor activity early in ontogeny. Experiments 1a and 1b tested ethanol-induced activity (0 or 2.5 g/kg) after a D1-like (SCH23390; 0, .015, .030, or .060 mg/kg) or a D2-like (sulpiride; 0, 5, 10, or 20 mg/kg) receptor antagonist, respectively. Ethanol-induced stimulation was suppressed by SCH23390 or sulpiride. The dopaminergic antagonists had no effect on blood ethanol concentration (Experiments 2a and 2b). In Experiment 3, 2.5 g/kg ethanol increased dopamine concentration in striatal tissue as well as locomotor activity in infant Wistar rats. Adding to our previous results showing a reduction in ethanol induced activity by a GABA B agonist or a nonspecific opioid antagonist, the present experiments implicate both D1-like and D2-like dopamine receptors in ethanol-induced locomotor stimulation during early development. According to these results, the same mechanisms that modulate ethanol-mediated locomotor stimulation in adult rodents seem to regulate this particular ethanol effect in the infant rat.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.