ArticleFunctional & integrative genomics2010
Genes influencing spinal bone mineral density in inbred F344, LEW, COP, and DA rats.
Article in Functional & integrative genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Integrating Transcriptome-Wide Association Study and mRNA Expression Profiling Identifies Novel Genes Associated With Osteonecrosis of the Femoral Head.Frontiers in genetics · 2021Article
- Collaborative cross mice in a genetic association study reveal new candidate genes for bone microarchitecture.BMC genomics · 2015Article
- Role of RHOT1 on migration and proliferation of pancreatic cancer.American journal of cancer research · 2015Article
- High-resolution genome screen for bone mineral density in heterogeneous stock rat.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Article
- Mitochondria: a kinase anchoring protein 1, a signaling platform for mitochondrial form and function.The international journal of biochemistry & cell biology · 2014Review
- Heterogeneous stock rat: a unique animal model for mapping genes influencing bone fragility.Bone · 2011Article
- Molecular genetic studies of gene identification for osteoporosis: the 2009 update.Endocrine reviews · 2010Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Previously, we identified the regions of chromosomes 10q12-q31 and 15p16-q21 harbor quantitative trait loci (QTLs) for lumbar volumetric bone mineral density (vBMD) in female F2 rats derived from Fischer 344 (F344) x Lewis (LEW) and Copenhagen 2331 (COP) x Dark Agouti (DA) crosses. The purpose of this study is to identify the candidate genes within these QTL regions contributing to the variation in lumbar vBMD. RNA was extracted from bone tissue of F344, LEW, COP, and DA rats. Microarray analysis was performed using Affymetrix Rat Genome 230 2.0 Arrays. Genes differentially expressed among the rat strains were then ranked based on the strength of the correlation with lumbar vBMD in F2 animals derived from these rats. Quantitative PCR (qPCR) analysis was performed to confirm the prioritized candidate genes. A total of 285 genes were differentially expressed among all strains of rats with a false discovery rate less than 10%. Among these genes, 18 candidate genes were prioritized based on their strong correlation (r (2) > 0.90) with lumbar vBMD. Of these, 14 genes (Akap1, Asgr2, Esd, Fam101b, Irf1, Lcp1, Ltc4s, Mdp-1, Pdhb, Plxdc1, Rabep1, Rhot1, Slc2a4, Xpo4) were confirmed by qPCR. We identified several novel candidate genes influencing spinal vBMD in rats.
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