ArticlePflugers Archiv : European journal of physiology2010
Compensatory regulation of the sodium/phosphate cotransporters NaPi-IIc (SCL34A3) and Pit-2 (SLC20A2) during Pi deprivation and acidosis.
Article in Pflugers Archiv : European journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- PI3KC3/BECLIN1-dependent lipophagy mediates phosphorus-induced reduction of hepatic lipid deposition in hybrid yellow catfish.Fish physiology and biochemistry · 2026Article
- The Intricacies of Renal Phosphate Reabsorption-An Overview.International journal of molecular sciences · 2024Review
- The Effects of Acid on Calcium and Phosphate Metabolism.International journal of molecular sciences · 2024Review
- Intestinal and Renal Adaptations to Changes of Dietary Phosphate Concentrations in Rat.Function (Oxford, England) · 2024Article
- Topology, tissue distribution, and transcriptional level of SLC34s in response to Pi and pH in grass carp Ctenopharyngodon idella.Fish physiology and biochemistry · 2021Article
- The Complexities of Organ Crosstalk in Phosphate Homeostasis: Time to Put Phosphate Sensing Back in the Limelight.International journal of molecular sciences · 2021Review
- Phosphate as a Signaling Molecule.Calcified tissue international · 2021Review
- Isolation and Characterization of Three Sodium-Phosphate Cotransporter Genes and Their Transcriptional Regulation in the Grass CarpInternational journal of molecular sciences · 2020Article
- Acanthamoeba castellanii phosphate transporter (AcPHS) is important to maintain inorganic phosphate influx and is related to trophozoite metabolic processes.Journal of bioenergetics and biomembranes · 2020Article
- Mechanisms of phosphate transport.Nature reviews. Nephrology · 2019Review
- Physiological regulation of phosphate by vitamin D, parathyroid hormone (PTH) and phosphate (Pi).Pflugers Archiv : European journal of physiology · 2019Review
- Therapeutic Interference With Vascular Calcification-Lessons From Klotho-Hypomorphic Mice and Beyond.Frontiers in endocrinology · 2018Review
- Biophysical aspects of biomineralization.Biophysical reviews · 2017Review
- HJournal of bioenergetics and biomembranes · 2017Article
- Prostaglandin-E2 Mediated Increase in Calcium and Phosphate Excretion in a Mouse Model of Distal Nephron Salt Wasting.PloS one · 2016Article
- Acetazolamide sensitive tissue calcification and aging of klotho-hypomorphic mice.Journal of molecular medicine (Berlin, Germany) · 2016Article
- Vascular Calcification Revisited: A New Perspective for Phosphate TransportCurrent cardiology reviews · 2015Article
- NH4Cl Treatment Prevents Tissue Calcification in Klotho Deficiency.Journal of the American Society of Nephrology : JASN · 2015Article
- Na+-independent phosphate transport in Caco2BBE cells.American journal of physiology. Cell physiology · 2014Article
- Alpha Klotho and phosphate homeostasis.Journal of endocrinological investigation · 2014Review
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2 authors.
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Abstract
The role of four Pi transporters in the renal handling of Pi was analyzed using functional and molecular methods. The abundance of NaPi-IIa, NaPi-IIc, and Pit-2 was increased by 100% in kidney from rats on a 0.1% Pi diet, compared to a 0.6% Pi diet. Pit-1 was not modified. Type II-mediated Pi uptake in Xenopus oocytes increased as the pH of the uptake medium increased, and the opposite occurred with Pit-1 and Pit-2. At pH 6.0, Pi uptake mediated through type II was approximately 10% of the uptake at pH 7.5, but the uptake through Pit-2 was 250% of the activity at pH 7.5. Real brush-border membrane vesicles (BBMV) responded to pH changes following the same pattern as type II transporters. Adaptation to a 0.1% Pi diet was accompanied by a 65% increase in the V (max) of BBMV Pi transport at pH 7.5, compared to a 0.6% Pi diet. The increase was only 11% at pH 6.0. Metabolic acidosis increased the expression of NaPi-IIc and Pit-2 in animals adapted to a low Pi diet, and phosphaturia was only observed in control diet animals. The combination of the pH effect, Pi adaptation, and metabolic acidosis suggests very modest involvement of Pit-2 in renal Pi handling. Real-time PCR and mathematical analyses of transport findings suggest that NaPi-IIa RNA accounts for 95% of all Pi transporters and that type II handles 97% of Pi transport at pH 7.5 and 60% of Pi transport at pH 6.0, depending on the pH and the physiological conditions.
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