ArticlePLoS biology2009
Differentiation driven changes in the dynamic organization of Basal transcription initiation.
Article in PLoS biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 66 citations in OpenAlex.
- Active DNA damage eviction by HLTF stimulates nucleotide excision repair.Molecular cell · 2022Article
- Global assessment of organ specific basal gene expression over a diurnal cycle with analyses of gene copies exhibiting cyclic expression patterns.BMC genomics · 2020Article
- Short Residence Times of DNA-Bound Transcription Factors Can Reduce Gene Expression Noise and Increase the Transmission of Information in a Gene Regulation System.Frontiers in molecular biosciences · 2020Article
- Cell-type specific concentration regulation of the basal transcription factor TFIIH in XPBCancer cell international · 2019Article
- Small molecule-based targeting of TTD-A dimerization to control TFIIH transcriptional activity represents a potential strategy for anticancer therapy.The Journal of biological chemistry · 2018Article
- Mechanistic insights in transcription-coupled nucleotide excision repair of ribosomal DNA.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Cbx2 stably associates with mitotic chromosomes via a PRC2- or PRC1-independent mechanism and is needed for recruiting PRC1 complex to mitotic chromosomes.Molecular biology of the cell · 2014Article
- UVB induces a genome-wide acting negative regulatory mechanism that operates at the level of transcription initiation in human cells.PLoS genetics · 2014Article
- Understanding nucleotide excision repair and its roles in cancer and ageing.Nature reviews. Molecular cell biology · 2014Review
- Independent RNA polymerase II preinitiation complex dynamics and nucleosome turnover at promoter sites in vivo.Genome research · 2014Article
- ELL, a novel TFIIH partner, is involved in transcription restart after DNA repair.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- Article
- Disruption of TTDA results in complete nucleotide excision repair deficiency and embryonic lethality.PLoS genetics · 2013Article
- The bacterial carbon-fixing organelle is formed by shell envelopment of preassembled cargo.PloS one · 2013Article
- Kinetics of endogenous mouse FEN1 in base excision repair.Nucleic acids research · 2012Article
- Generation of DNA single-strand displacement by compromised nucleotide excision repair.The EMBO journal · 2012Article
- The prolactin gene: a paradigm of tissue-specific gene regulation with complex temporal transcription dynamics.Journal of neuroendocrinology · 2012Review
- In vivo Polycomb kinetics and mitotic chromatin binding distinguish stem cells from differentiated cells.Genes & development · 2012Article
- Assembly of the transcription machinery: ordered and stable, random and dynamic, or both?Chromosoma · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
Studies based on cell-free systems and on in vitro-cultured living cells support the concept that many cellular processes, such as transcription initiation, are highly dynamic: individual proteins stochastically bind to their substrates and disassemble after reaction completion. This dynamic nature allows quick adaptation of transcription to changing conditions. However, it is unknown to what extent this dynamic transcription organization holds for postmitotic cells embedded in mammalian tissue. To allow analysis of transcription initiation dynamics directly into living mammalian tissues, we created a knock-in mouse model expressing fluorescently tagged TFIIH. Surprisingly and in contrast to what has been observed in cultured and proliferating cells, postmitotic murine cells embedded in their tissue exhibit a strong and long-lasting transcription-dependent immobilization of TFIIH. This immobilization is both differentiation driven and development dependent. Furthermore, although very statically bound, TFIIH can be remobilized to respond to new transcriptional needs. This divergent spatiotemporal transcriptional organization in different cells of the soma revisits the generally accepted highly dynamic concept of the kinetic framework of transcription and shows how basic processes, such as transcription, can be organized in a fundamentally different fashion in intact organisms as previously deduced from in vitro studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.