ArticleNature immunology2009
The gut feeling of Treg cells: IL-10 is the silver lining during colitis.
Article in Nature immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Three polymorphisms in the IL-10 gene and the risk of HCV infection: a meta-analysis plus a Chinese Association Study involving 1140 subjects.Epidemiology and infection · 2013Pooled it
- Hepatitis B virus promotes liver cancer by modulating the immune response to environmental carcinogens.Nature communications · 2025Article
- CREB regulates Foxp3Frontiers in immunology · 2025Article
- The Role ofMicroorganisms · 2024Review
- Regulatory T cell function in autoimmune disease.Journal of translational autoimmunity · 2021Review
- Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota.Theranostics · 2021Article
- IL-33 Protects Mice against DSS-Induced Chronic Colitis by Increasing Both Regulatory B Cell and Regulatory T Cell Responses as Well as Decreasing Th17 Cell Response.Journal of immunology research · 2018Article
- Sodium selenite ameliorates dextran sulfate sodium-induced chronic colitis in mice by decreasing Th1, Th17, and γδT and increasing CD4(+)CD25(+) regulatory T-cell responses.World journal of gastroenterology · 2017Article
- Impact of Age, Caloric Restriction, and Influenza Infection on Mouse Gut Microbiome: An Exploratory Study of the Role of Age-Related Microbiome Changes on Influenza Responses.Frontiers in immunology · 2017Article
- IL-10 Modulates Th17 Pathogenicity during Autoimmune Diseases.Journal of clinical & cellular immunology · 2016Article
- Epigallocatechin-3-gallate-induced inhibition of interleukin-6 release and adjustment of the regulatory T/T helper 17 cell balance in the treatment of colitis in mice.Experimental and therapeutic medicine · 2015Article
- Nuclear matrix protein SMAR1 control regulatory T-cell fate during inflammatory bowel disease (IBD).Mucosal immunology · 2015Article
- Effect of resveratrol on Treg/Th17 signaling and ulcerative colitis treatment in mice.World journal of gastroenterology · 2015Article
- A transgenic probiotic secreting a parasite immunomodulator for site-directed treatment of gut inflammation.Molecular therapy : the journal of the American Society of Gene Therapy · 2014Article
- Animal models of inflammatory bowel disease: a review.Inflammopharmacology · 2014Review
- Preventing acute gut wall damage in infectious diarrhoeas with glycosylated dendrimers.EMBO molecular medicine · 2012Article
- M cell-targeted mucosal vaccine strategies.Current topics in microbiology and immunology · 2012Review
- Intestinal dendritic cells in the pathogenesis of inflammatory bowel disease.World journal of gastroenterology · 2011Review
- Droplet-based microfluidic platforms for single T cell secretion analysis of IL-10 cytokine.Biosensors & bioelectronics · 2011Article
- Targeting IL-12/IL-23 by employing a p40 peptide-based vaccine ameliorates TNBS-induced acute and chronic murine colitis.Molecular medicine (Cambridge, Mass.) · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulatory T cells that express the transcription factor Foxp3 are pivotal in suppressing autoimmune responses. A report in this issue describes a key role for interleukin 10 produced by lamina propria macrophages in maintaining Foxp3 expression during inflammatory responses in the intestine.
Indexed as
Identifiers
19841645What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.