ArticleLaboratory investigation; a journal of technical methods and pathology2009
Identification of a bone marrow-derived mesenchymal progenitor cell subset that can contribute to the gastric epithelium.
Article in Laboratory investigation; a journal of technical methods and pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Mesenchymal stem cells and cancer therapy: insights into targeting the tumour vasculature.Cancer cell international · 2021Review
- Dynamic Changes of the Bone Marrow Niche: Mesenchymal Stromal Cells and Their Progeny During Aging and Leukemia.Frontiers in cell and developmental biology · 2021Review
- Strategies for treating oesophageal diseases with stem cells.World journal of stem cells · 2020Review
- Comparison of clinicopathological features and prognosis of gastric cancer located in the lesser and greater curve.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2017Article
- The potential of cell sheet technique on the development of hepatocellular carcinoma in rat models.PloS one · 2017Article
- Circulating tumor cells expressing cancer stem cell marker CD44 as a diagnostic biomarker in patients with gastric cancer.Oncology letters · 2017Article
- Gastric cancer stem cells: evidence, potential markers, and clinical implications.Journal of gastroenterology · 2016Review
- Peripheral trafficking of bone-marrow-derived stem cells in patients with different types of gastric neoplasms.Oncoimmunology · 2016Article
- Detection of circulating tumor cells by p75NTR expression in patients with esophageal cancer.World journal of surgical oncology · 2016Article
- Potential of Mesenchymal Stem Cell based application in Cancer.International journal of hematology-oncology and stem cell research · 2015Review
- Human Mesenchymal Stromal Cells Transplantation May Enhance or Inhibit 4T1 Murine Breast Adenocarcinoma through Different Approaches.Stem cells international · 2015Article
- Fluorescence activated enrichment of CD146+ cells during expansion of human bone-marrow derived mesenchymal stromal cells augments proliferation and GAG/DNA content in chondrogenic media.BMC musculoskeletal disorders · 2014Article
- Mesenchymal stem cells induce epithelial proliferation within the inflamed stomach.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Gastric cancer stem cells in gastric carcinogenesis, progression, prevention and treatment.World journal of gastroenterology · 2014Review
- Effect of Helicobacter pylori infection on stromal-derived factor-1/CXCR4 axis in bone marrow-derived mesenchymal stem cells.Advanced biomedical research · 2014Article
- Role of stromal-epithelial interaction in the formation and development of cancer cells.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2013Article
- Helicobacter pylori CagA: From Pathogenic Mechanisms to Its Use as an Anti-Cancer Vaccine.Frontiers in immunology · 2013Review
- Cancer stem cells: the 'heartbeat' of gastric cancer.Journal of gastroenterology · 2013Review
- Sonic hedgehog mediates the proliferation and recruitment of transformed mesenchymal stem cells to the stomach.PloS one · 2013Article
- Helicobacter pylori infection induced gastric cancer; advance in gastric stem cell research and the remaining challenges.Gut pathogens · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Recent studies with Helicobacter-infected mice have shown that bone marrow-derived cells can repopulate the gastric epithelium and progress to cancer. However, it has not been established which cellular subset can potentially contribute to the epithelium. The aim of this study was to investigate the ability of bone marrow-derived mesenchymal stem cells (MSCs) that express cytokeratin 19 (K19) to contribute to the gastric epithelium. MSCs cultures were established from whole bone marrow and expression of K19 was detected in a minority (1 of 13) of clones by real-time PCR and immunostaining. Transfection of a K19-green fluorescent protein (GFP) vector and isolation of GFP-expressing colonies generated high K19-expressing MSC clones (K19GFPMSC). Incubation of MSCs with gastric tissue extract markedly induced mRNA expression of gastric phenotypic markers and was observed to a greater extent in K19GFPMSCs compared with parental MSCs and mock transfectants. Both K19GFPMSCs and GFP-labeled control MSCs gave rise to gastric epithelial cells after injection into the murine stomach. In addition, after blastocyst injections, K19GFPMSCs gave rise to GFP-positive gastric epithelial cells in all 13 pups, whereas only 3 of 10 offspring showed GFP-positive gastric epithelial cells after injection of GFP-labeled control MSCs. Although K19 expression could not be detected in murine whole bone marrow, H. felis infection increased K19-expressing MSCs in the circulation. Taken together, our results show that bone marrow-derived MSCs can contribute to the gastric epithelium. The K19-positive MSC fraction that is induced by chronic H. felis infection appears to be the important subset in this process.
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