Evidence map›Paper›PMID 19841289›Full record

ArticleHypertension (Dallas, Tex. : 1979)2009

Role of proinflammatory cytokines and redox homeostasis in exercise-induced delayed progression of hypertension in spontaneously hypertensive rats.

Deepmala Agarwal, Masudul Haque, Srinivas Sriramula, Nithya Mariappan, Romain Pariaut, Joseph Francis

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 4 pooled it
21.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 4 syntheses or guidelines pooled it, 103 citations in OpenAlex.

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  17. Metabolic and inflammatory health in SARS-CoV-2 and the potential role for habitual exercise in reducing disease severity.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Deepmala AgarwalComparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, 1909 Skip Bertman Dr, Baton Rouge, LA 70803, USA.
Masudul Haque
Srinivas Sriramula
Nithya Mariappan
Romain Pariaut
Joseph Francis
Louisiana State University · US

Funding

Cytokine-induced NeurohumoralExcitation in Heart FailureR01HL080544 · NHLBI · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI FRANCIS, JOSEPH · 2005 to 2009
$1.7M
NHLBI NIH HHS HL-80544NHLBI NIH HHS R01 HL080544
6 · The paper itself

Abstract

Hypertension is a well-known risk factor for various cardiovascular diseases. Recently, exercise has been recommended as a part of lifestyle modification for all hypertensive patients. However, the precise mechanisms of exercise training (ExT)-induced effects on the development of hypertension are poorly understood. Therefore, we hypothesized that chronic ExT would delay the progression of hypertension in young spontaneously hypertensive rats (SHRs). In addition, we explored whether the beneficial effects of chronic ExT were mediated by reduced proinflammatory cytokines and improved redox status. We also investigated the involvement of nuclear factor-kappaB in exercise-induced effects. To test our hypotheses, young normotensive (Wistar-Kyoto) and SHRs were given moderate-intensity ExT for 16 weeks. Blood pressure was determined by the tail-cuff method, and cardiac function was assessed by echocardiography. Myocardial total reactive oxygen species and superoxide production were measured by electron paramagnetic resonance spectroscopy; tumor necrosis factor-alpha, interleukin-1beta, gp91(phox), and inducible NO synthase by real-time PCR; and nuclear factor kappaB activity by electrophoretic mobility shift assay. Chronic ExT in hypertensive rats resulted in significantly reduced blood pressure, reduced concentric hypertrophy, and improved diastolic function. ExT significantly reduced proinflammatory cytokines and inducible NO synthase, attenuated total reactive oxygen species and superoxide production, and increased antioxidants in SHRs. ExT also resulted in increased NO production and decreased nuclear factor kappaB activity in SHRs. In summary, chronic ExT delays the progression of hypertension and improves cardiac function in young SHRs; these ExT-induced beneficial effects are mediated by reduced proinflammatory cytokines and improved redox homeostasis via downregulation of nuclear factor-kappaB.

Indexed as

AnimalsBlood PressureBody WeightCardiomegalyDiastoleDisease ProgressionHomeostasisHypertensionInterleukin-1betaMaleMembrane GlycoproteinsNADPH Oxidase 2NADPH OxidasesNF-kappa BNitric OxideNitric Oxide Synthase Type IICybb protein, ratInterleukin-1betaMembrane GlycoproteinsNADPH Oxidase 2NADPH OxidasesNF-kappa BNitric OxideNitric Oxide Synthase Type IINorepinephrineNos2 protein, ratPeroxynitrous AcidTumor Necrosis Factor-alpha

Identifiers

PMID19841289
PMCPMC2780026
OpenAlexW2005608809

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.