Evidence map›Paper›PMID 19841095›Full record

ArticleGenetics2010

Genetic testing of the hypothesis that hybrid male lethality results from a failure in dosage compensation.

Daniel A Barbash

Abstract read
In one paragraph

Article in Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Aberrant X chromosome dosage compensation causes hybrid male inviability inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Review
  3. Article
  4. Article
  5. GFZF, a GlutathioneMolecular and cellular biology · 2018
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Daniel A BarbashDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA. dab87@cornell.edu

Funding

Molecular Genetics of Drosophila Hybrid LethalityR01GM074737 · NIGMS · CORNELL UNIVERSITY ITHACA · PI BARBASH, DANIEL A · 2005 to 2022
$4.7M
NIGMS NIH HHS R01 GM074737
6 · The paper itself

Abstract

Several recent studies have suggested that F(1) hybrid male lethality in crosses between Drosophila melanogaster and D. simulans is due to a failure in dosage compensation, caused by incompatibilities between D. simulans dosage compensation proteins and the D. melanogaster X chromosome. Contrary to the predictions of this hypothesis, mutations in four essential D. melanogaster dosage compensation genes are shown here to moderately increase rather than decrease hybrid male viability.

Indexed as

Models, GeneticAnimalsCrosses, GeneticDeathDosage Compensation, GeneticDrosophila melanogasterFemaleHybridization, GeneticMaleMutationReproducibility of ResultsX Chromosome

Identifiers

PMID19841095
PMCPMC2815928

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.