ArticleSchizophrenia research2009
Verbal fluency deficits and altered lateralization of language brain areas in individuals genetically predisposed to schizophrenia.
Article in Schizophrenia research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Aberrant brain language network in schizophrenia spectrum disorder: a systematic review of its relation to language signs beyond symptoms.Frontiers in psychiatry · 2024Pooled it
- Neurocognition in youth and young adults under age 30 at familial risk for schizophrenia: a quantitative and qualitative review.Cognitive neuropsychiatry · 2013Pooled it
- Effective stimulation sites and networks for substantia nigra pars reticulata deep brain stimulation for auditory verbal hallucinations in schizophrenia.Translational psychiatry · 2026Article
- Pars Triangularis Volume Asymmetry and Schneiderian First Rank Symptoms in Antipsychotic-naïve Schizophrenia.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2021Article
- Abnormalities in hemispheric lateralization of intra- and inter-hemispheric white matter connections in schizophrenia.Brain imaging and behavior · 2021Article
- Clinical psychopathology in youth at familial high risk for psychosis.Early intervention in psychiatry · 2019Article
- Theoretical Modeling of Cognitive Dysfunction in Schizophrenia by Means of Errors and Corresponding Brain Networks.Frontiers in psychology · 2018Review
- Disruptions in the left frontoparietal network underlie resting state endophenotypic markers in schizophrenia.Human brain mapping · 2017Article
- Self-disturbances as a possible premorbid indicator of schizophrenia risk: a neurodevelopmental perspective.Schizophrenia research · 2014Review
- The XY gene hypothesis of psychosis: origins and current status.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2013Review
- Altered language network activity in young people at familial high-risk for schizophrenia.Schizophrenia research · 2013Article
- Gray matter alterations in schizophrenia high-risk youth and early-onset schizophrenia: a review of structural MRI findings.Child and adolescent psychiatric clinics of North America · 2013Review
- Neuroimaging schizophrenia: a picture is worth a thousand words, but is it saying anything important?Current psychiatry reports · 2013Review
- Alterations in the cerebral white matter of genetic high risk offspring of patients with schizophrenia spectrum disorder.Progress in neuro-psychopharmacology & biological psychiatry · 2013Article
- Brain gray matter phenotypes across the psychosis dimension.Psychiatry research · 2012Article
- Dissociable morphometric differences of the inferior parietal lobule in schizophrenia.European archives of psychiatry and clinical neuroscience · 2012Article
- Alterations in brain structures underlying language function in young adults at high familial risk for schizophrenia.Schizophrenia research · 2012Article
- Progressive alterations of the auditory association areas in young non-psychotic offspring of schizophrenia patients.Journal of psychiatric research · 2011Article
- Abnormalities of the corpus callosum in non-psychotic high-risk offspring of schizophrenia patients.Psychiatry research · 2011Article
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Authors and funding
10 authors.
Funding
Abstract
Alterations of verbal fluency may correlate with deficits of gray matter volume and hemispheric lateralization of language brain regions like the pars triangularis (PT) in schizophrenia. Examining non-psychotic individuals at high genetic risk (HR) for schizophrenia may clarify if these deficits represent heritable trait markers or state dependent phenomena. We assessed adolescent and young adult HR subjects (N=60) and healthy controls (HC; N=42) using verbal fluency tests and Freesurfer to process T1-MRI scans. We hypothesized volumetric and lateralization alterations of the PT and their correlation with verbal fluency deficits. HR subjects had letter verbal fluency deficits (controlling for IQ), left PT deficits (p=.00), (controlling ICV) and reversal of the L>R PT asymmetry noted in HC. Right Heschl's (p=.00), left supramarginal (p=.00) and right angular gyrii (p=.02) were also reduced in HR subjects. The L>R asymmetry of the Heschl's gyrus seen in HC was exaggerated and asymmetries of L>R of supramarginal and R>L of angular gyri, seen in HC were attenuated in HR subjects. L>R asymmetry of the PT predicted better verbal fluency across the pooled HR and HC groups. Young relatives of schizophrenia patients have verbal fluency deficits, gray matter volume deficits and reversed asymmetry of the pars triangularis. A reversed structural asymmetry of the PT in HR subjects may impair expressive language abilities leading to verbal fluency deficits. Volumetric deficits and altered asymmetry in inferior parietal and Heschl's gyrii may accompany genetic liability to schizophrenia.
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